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List of Publications

  1. Sur, B.; Adak, M. M.; Pathak, T.; Hazra, B.; Banerjee, A. Applications of ammonium molybdate: oxidation of arylmethanol to aromatic aldehydes. Synthesis1985, 652-654.

  2. Hering, G.; Stoecklein-Schneiderwind, R.; Ugi, I.; Pathak, T.; Balgobin, N.; Chattopadhyaya, J. Preparation and properties of chloro-N,N-dialkylamino 2,2,2-trichloroethoxy-and chloro-N,N-dialkylamino-2,2,2-trichloro-1,1-dimethylethoxyphosphines and their deoxynucleoside phosphitamidates. Nucleosides Nucleotides1985, 4, 169-171.

  3. Pathak, T. ; Chattopadhyaya, J. The 2’-hydroxyl function assisted cleavage of the internucleotide phosphotriester bond of a ribonucleotide under acidic condition. Acta Chem. Scand. Ser B1985, 39, 799-806.

  4. Bazin, H.; Zhou, X. X.; Welch, C. J.; Pathak, T.; Nyilas, A.; Chattopadhyaya, J. Some observations on the 13C-NMR assignments of the pentofuranose moiety of b -D-nucleosides. Chemica Scripta1986, 26, 17-19.

  5. Pathak, T. ; Chattopadhyaya, J. Preparation of 2’-O-methyl ethers of adenosine and uridine using 2’,3’-(dibutylstannylene)-nucleosides and diazomethane. Chemica Scripta1986, 26, 135-139.

  6. Ugi, I.; Bauer, J.; Fontain, E.; Gotz, J.; Hering, G.; Jakob, P.; Landgraf, B.; Karl, R.; Lemmen, P.; Stocklein-Schneiderwind, R.; Schwarz, R.; Sluka, P.; Balgobin, N.; Chattopadhyaya, J.; Pathak, T.; Zhou, X. X.. New phosphorylating reagents and protective group techniques for oligonucleotide synthesis as well as computer assistance in the design of reagents. Chemica Scripta1986, 26, 205-215.

  7. Pathak, T. ; Bazin, H.; Chattopadhyaya, J. Synthesis of 2’-deoxy-2’(S)-deuterio- and 2’-deoxy-2’(R)-deuterio- b -D-nucleosides. Tetrahedron1986, 42, 5427-5441.

  8. Pathak, T. ; Chattopadhyaya, J. A regio and stereoselective synthesis of 2’,2”,3’,4’-tetradeuterio-2’-deoxynucleosides. Tetrahedron1987, 43, 4227-4234.

  9. Wu, J. C.; Pathak, T.; Bazin, H.; Chattopadhyaya, J. Regiospecific synthesis of deuterium labeled 2’-deoxyribonucleosides. Nucleic Acids Res. Symposium Ser.1987, no 18, 21-24.

  10. Wu, J. C.; Pathak, T.; Tong, W.; Vial, J. M.; Remaud, G.; Chattopadhyaya, J. New synthesis of 2’,3’-dideoxy-2,3’-disubstituted and –2’-monosubstituted uridines and adenosines by Michael addition reactions. Tetrahedron1988, 44, 6705-6722.

  11. Pathak, T. ; Thomas, N. F.; Akhtar, M.; Gani, D. Synthesis of [4- 2H 2]-, (4-R)[4- 2H 1]-, (4-S)[4- 2H 1]-4-(methylnitrosoamino)-1-(3’-pyridyl)-1-butanone, C-4 deuteriated isotopomers of the procarcinogen NNK. Tetrahedron1990, 46, 1733-1744.

  12. Sakthivel, K.; Kumar, R. K.; Pathak, T. Reactions of dimesylthymidines with secondary amines: easy access to 3’,5’-dideoxy-3’-substituted-5’-alkylaminothymidines-new classes of potential antiviral aminonucleosides. Tetrahedron1993, 49, 4365-4372.

  13. Sakthivel, K.; Bera, S.; Pathak, T . One-step synthesis of C-2 dialkylamino-substituted 2’,3’-O-anhydro-lyxo-uridines: first report on the opening of 2,2’-O-anhydro-bridge of 2,2’-O-anhydrouridine by secondary amines. Tetrahedron1993, 49, 10387-10392.

  14. Sakthivel, K.; Pathak, T.; Suresh, C. G . Reactions of 2’,3’-di-O-mesyl-lyxo-uridine with secondary amines: first report on the one-pot conversion of mesylated nucleosides to enaminonucleosides and the crystal structure of a -enamine. Tetrahedron1994, 50, 13251-13260.

  15. Bera, S.; Langley, G. J.; Pathak, T. Opening of 2’,3’-O-anhydro-ring of 2’,3’-O-anhydro-lyxo-uridine by alkyl- and arylamines. Easy synthesis and preparative uses of 2’-deoxy-2’-alkylamino-xylo- and 3’-deoxy-3’-alkylamino-ara-uridines. Tetrahedron1995, 51, 1459-1470.

  16. Bera, S.; Sakthivel, K.; Langley, G. J.; Pathak, T. 3’-Deoxy-3’-(vinylsulfonyl)thymidine-a new reactive analogue of AZT: its synthesis and reactivities towards various nucleophiles. Tetrahedron, 1995, 51, 7857-7866.

  17. Sakthivel, K.; Suresh, C. G.; Pathak, T. 5’-O-Benzoyl-2’-keto-3’-deoxy- a -uridine: first unambiguous synthesis, crystal structure and its use to establish the anomerisation of 2’-ketouridines under basic conditions. Tetrahedron1996, 52, 1767-1772.

  18. Suresh, C. G.; Sakthivel, K.; Pathak, T. 5’-O-Benzoyl-2’-keto-3’-deoxy- a -uridine, C 16H 14N 2O 6. Acta Cryst. 1996, C52, 1776-1779.

  19. Sakthivel, K; Pathak, T. One-pot deoxygenative conversion of a ribonucleoside to enaminonucleosides involving 1,2-hydride shift rearrangement. Tetrahedron1996, 52, 4877-4882.

  20. Bera, S.; Langley, G. J.; Pathak, T. Sugar modified uridine bisvinylsulfone: synthesis of a bifunctionalised nucleoside Michael acceptor and its use in stereoselective tandem cyclisation. J. Org. Chem. 1998, 63, 1754-1760.

  21. Bera, S.; Pathak, T. Thermal degradation of sugar-modified uridine N-oxides: olefination, oxazolidination and rearrangements . Tetrahedron 1999 , 55, 13051-13062.

  22. Ravindran, B.; Pathak, T. Thermal degradation of designed carbohydrate N-oxides:a single methodology for the synthesis of ketoses, enolates and branched chain sugars. J. Org. Chem . 1999, 64, 9715-9718.

  23. Ravindran, B.; Sakthivel, K.; Suresh, C. G.; Pathak, T. Diastereoselective addition of amines to vinylsulfone modified carbohydrates: a highly flexible methodology for the synthesis of new classes of deoxyaminosugars. J. Org. Chem.2000, 65, 2637-2641.

  24. Suresh, C. G.; Ravindran, B.; Rao, K. N.; Pathak, T. Comparison of the crystal structures of the two anomers of methyl 2-N-benzylamino-2,3-dideoxy-4, 6-O-(phenylmethylene)-3-C-phenylsulfonyl-D-glucopyranosides. Acta Cryst . 2000, C56, 1030-1032.

  25. Kuder, N.; Zelinski, T.; Pathak, T.; Seitz, O; Waldmann, H. Synthesis of a triply phosphorylated pentapeptide from human t-protein. Bioorg. Med. Chem.2000, 8, 2433-2439.

  26. Ravindran, B.; Deshpande, S. G.; Pathak, T. Vinyl sulfone-modified carbohydrates: First general route to D-lividosamine (2-amino-2,3-dideoxy-D-glucose) and its new analogues. Tetrahedron2001, 57, 1093-1098.

  27. Ravindran, B; Pathak, T. Synthesis of mono- and di-azido-hexenopyranoses with N-alkyl and N,N-dialkyl amino groups at C-2 position: Intermediates for accessing new polyaminosugars. Ind. J. Chem. B (Special issue dedicated to Prof. U. R. Ghatak on the occasion of his 70th birth anniversary), 2001, 40, 1114-1120. (Errata: Ind. J. Chem. B. 2002, 41, 1100)

  28. Sanki, A. K.; Pathak, T. A glycosylation driven strategy for the synthesis of anomerically pure vinyl sulfone-modified pent-2-enofuranoses and hex-2-enopyranoses. Synlett 2002 , 1241-1244.

  29. Suresh, C. G.; Ravindran, B.; Pathak, T.; Rao, K. N.; Sasidharaprasad, J.; Lokanath, N. K.. Structural studies on C-2 substitution in a new set of synthetic aminodideoxy sugars: the steric bulk at C-2 influences the puckering of the pyranose ring. Carbohydr. Res, 2002, 337(16), 1507-1512.

  30. Sanki , A. K.; Suresh, C. G.; Falgune, U. D.; Pathak, T . Anomeric configuration directed diastereoselective C-C bond formation in vinyl sulfone-modified carbohydrates: A general route to branched-chain sugars. Org. Lett. 2003, 5 , 1285-1288.

  31. Sanki, A. K.; Pathak, T. Synthesis of anomerically pure vinyl sulfone-modified pent-2-enofuranosides and hex-2-enopyranosides: A group of highly reactive Michael acceptors for accessing carbohydrate based synthons . Tetrahedron, 2003, 59 , 7203-7214 .

  32. Deshpande, S. G.; Pathak, T. Synthesis and synthetic applications of 1-(3-O-tosyl- b -D-glucopyranosyl) thymines: toward new classes of hexopyranosyl pyrimidines. Tetrahedron Lett. 2004, 45, 2255-2258.

  33. Pathak, T . On the bis-heteronucleophilic Michael addition to divinyl sulfone: a new efficient access to macrocycles by Marie-Laure Teyssot, Martine Fayolle, Christian Philouze and Claude Dupuy. Eur. J. Org. Chem. 2004, 3361.

  34. Bera, S.; T Pathak, T. Synthesis and reactions of allenic sulfone-modified thymidine: the first allenic sulfone to alkylate deoxyadenosine. Synlett2004, 2147-2150.  

  35. Das, I.; Suresh, C. G.; Pathak, T. A diastereoselective and general route to 5-amino-5-deoxysugars: influence of C-3 substitution on the addition of amines to C-5 of vinyl sulfone-modified hex-5-enofuranosyl carbohydrates. J. Org. Chem. 2005, 20, 8047-8054.

  36. Maiti, T. K.; De, S.; Dasgupta, S.; Pathak, T. 3’-N-Alkylamino-3’-deoxy-ara-uridines: a new class of potential inhibitors of ribonuclease A and angiogenin. Bioorg. Med. Chem. 2006 , 14, 1221-1228.

  37. Das, I.; Pathak, T. Desulfonylation with Mg-MeOH-NiBr 2: an expedient reagent system for the synthesis of 2-amino-2,3-dideoxy furanosides. Org. Lett. 2006 , 8, 1303-1306 .

  38. Leonidas, D. D.; Maiti, T. K.; Samanta, A.; Dasgupta, S.; Pathak, T. Zographos, S. E.; Oikonomakos, N. G. The binding of 3´-N-piperidine-4-carboxyl-3´-deoxyara-uridine to ribonuclease A in the crystal. Bioorg. Med. Chem. 2006 , 14, 6055-6064.

  39. Deshpande, S. G.; Pathak, T. A general and efficient route to 3’-deoxy-3’-N-, S- and C-substituted altropyranosyl thymines from 2’,3’-O-anhydro-mannopyranosylthymidine. Tetrahedron 2007, 63, 602-608.

  40. Das, I.; Pal, T. K.; Suresh, C. G.; Pathak, T. Diastereoselective C-C bond formation at C-5 of vinyl sulfone-modified hex-5-enofuranosyl carbohydrates: a general route to branched-chain sugars and beyond. J. Org. Chem. 2007 , in press.

    Review Articles

  41. Pathak, T . Synthesis of azidothymidine. NCL Bulletine, 1993, XVIII, 5-15. (non-refereed)

  42. Pathak, T. ; Waldmann, H. Enzymes and protecting group chemistry. Current Opinion in Chemical Biology. 1998, 2, 112-120.

  43. Pathak, T . Azidonucleosides: Synthesis, reactions and biological properties. Chem. Rev. 2002, 102, 1623-1667.

  44. Sanki, A.; Pathak, T. Vinyl sulfone-modified carbohydrates: synthesis and reactions with nucleophiles . Proc. Indian Natn. Sci. Acad. 2005 , 71A, 245-266.

    Chapters in books

  45. Pathak, T. ; Waldmann, H. Enzymatic protecting group techniques in organic synthesis in Stereoselective Biocatalysis. Ed. R Patel. Marcel Dekker, N.Y.2000 (ISBN: 0-8247-8282-8).

  46. Pathak, T . Vinylsulfone-modified carbohydrates: synthesis and properties in Trends in Carbohydrate Chemistry. Ed. P L Soni, Surya International Publications, Dehra Dun, 2000. Vol 6. pp 65-78.

  47. Pathak, T. ; Waldmann, H. Enzymatic deprotection of peptides in Synthesis of Peptides and Peptidomimetics. Eds M Goodman, C Toniolo, L Moroder, A Felix. Houben-Weyl Methods of Organic Chemistry. Thieme, Stuttgart. 2002 (ISBN: 1588900223 / 3132196045 ).

    Papers communicated/manuscript in preparation

  48. Das, I.; Pal, T. K.; Pathak, T. A Diastereoselective Michael initiated ring closure on vinyl sulfone-modified carbohydrates: a stereospecific and general route to a -substituted cyclopropanes. Communicated.

  49. Sanki, A.; Pathak, T. Diastereoselective addition of nitrogen containing aromatic heterocycles to vinyl sulfone-modified carbohydrates. Communicated.

  50. Pal, T. K.; Pathak, T. First report on the attachment of bisvinyl sulfone to chiral appendages like carbohydrates: Synthesis of first series of highly reactive bis vinylsulfone-modified carbohydrates. Manuscript in preparation.

  51. Bhattacharya, R.; Pathak, T. Remarkable influence of protecting groups on the selectivity of addition of amines to vinyl sulfone-modified hex-2-enopyranosides. Manuscript in preparation.
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