Karthik Sambath

 

Department of Chemistry

Indian Institute of Technology Kharagpur

Kharagpur, West Bengal, INDIA - 721 302

 

Email: skarthik@chem.iitkgp.ernet.in

Ph: 8101535166

 

 

 

Research Interests

The focus of our research is to understand the Photochemistry of Organic molecules in various applications

• Synthesis of Photoresponisve nanocarrier for targeted and control delivery of active molecules.

• Synthesizing of organic fluorescent molecules and Quantum Dots

• Design and synthesis of control polymerization (dendrimer  and control ring opening polymerization)

Publications

• S. Karthik, S.Nayak, R.Selva Kumar, Amrita Paul, Sudip Kumar Ghosh, N. D. Pradeep Singh. Hypoxia assisted Photoresponsive Coumarin Polycaprolactone nanoparticles for Cocktail Anticancer Drug Delivery. (Submitted)

• S. Karthik, B. N. Prashanth Kumar, Mahitosh Mandal, N. D. Pradeep Singh. Targeted, Image Guided & Dually Locked Photoresponsive Drug Delivery System. J. Mater. Chem. B,  2015, , 3, 728 – 732.

• S. Karthik, Avijit Jana, Biswajit Saha, B. Krishna Kalyani, Sudip Kumar Ghosh, Yanli Zhao, N. D. Pradeep Singh. Synthesis and In Vitro Evaluation of Charge Reversal Photoresponsive Quinoline Tethered Mesoporous Silica for Targeted Drug Delivery. J. Mater. Chem. B, 2014, 2, 7971-7977.

• S. Karthik, Biswajit Saha, Sudip Kumar Ghosh, N. D. Pradeep Singh; Photoresponsive quinoline tethered fluorescent carbon dots for regulated anticancer drug delivery. Chem. Comm., 2013, 49, 10471-10473.

• S. Karthik, Nagaprasad Puvvada,  B. N. Prashanth Kumar, Shashi Rajput, Amita Pathak, Mahitosh Mandal, N. D. Pradeep Singh. Photoresponsive Multifunctional Magnetic Nanoparticles for Targeted and Regulated Delivery of Anticancer drug. ACS Appl. Mater. Interfaces, 2013, 5, 5232−5238.

• S. Karthik, Chandrakala, Padma Venkat. Phytochemical and Microscopic Analysis of Tubers of Ipomoea mauritiana acq.(Convolvulaceae), J.PHCOG.MAG, 2009, 272-278.

• Moumita Gangopadhyay, Sourav K. Mukhopadhyay, S. Karthik, Shrabani Barman, N. D. Pradeep Singh. Targeted Photoresponsive TiO2-Coumarin nanoconjugate for efficient Combination therapy in MDA-MB-231 breast cancer cells: Synergic effect of PDT and Anticancer drug Chlorambucil. Just accepted
  Med. Chem. Commun., 2015. DOI: 10.1039/C4MD00481G,

• Nilanjana Chowdhury, Moumita Gangopadhyay, S. Karthik, Mithu Baidya, S.K. Ghosh, N.D. Pradeep Singh.Synthesis, photochemistry, DNA cleavage/binding and cytotoxic properties of fluorescent quinoxaline and quinoline hydroperoxides. Journal of Photochemistry and Photobiology B: Biology,  2014, 130,188-198.

• Avijit Jana, Biswajit Saha, S. Karthik, Sharabani Barman, Mohammed Ikbal, Sudip Kumar Ghosh ,  N. D. Pradeep Singh. Fluorescent photoremovable precursor (acridin- 9-ylmethyl) ester: synthesis, photophysical, photochemical and biological applications, Photochem. Photobiol. Sci. 2013, 12, 1041-52. 

• Nilanjana Chowdhury, Sansa Dutta, S. Karthick, Anakuthil Anoop, Swagata Dasgupta, N.D. Pradeep Singh. Azido carbonyl compounds as DNA cleaving agents.  Journal of Photochemistry and Photobiology B: Biology,  2012, 115, 25–34.

 

Presentations and Participations                                                                                                  

• Recipient of Best Oral  presentation award in “Recent Development in Chemical Science & Technology: Young Scientists’ Meet” (RDCST 2014)

• Participated in Fourth One Day “Research Scholar Day” Symposium held in the department of Chemistry, Indian Institute of Technology, Kharagpur, India

• Participated in Third One Day “Research Scholar Day” Symposium held in the department of Chemistry, Indian Institute of Technology, Kharagpur, India

• Participated in International Level Symposium on “Current Trends in Organic Synthesis” on November 20-22, 2008, The Department of Organic Chemistry, Indian Institute of Science, Bangalore

• Awarded 1st  prize in Model making, 2005, (Drug Design) Bishop Heber College, Trichy, India

 

Background

• 2010 - PhD with Prof.N.D.Pradeep Singh at Indian Institute of Technology,Kharagpur,India.

• M.Sc Chemistry (2005-2007) - Bishop Heber College, Trichirapalli, India

• B.Sc Chemistry (2002-2005) - Bishop Heber College, Trichirapalli, , India

 

Fellowships

Gate 2010 Research Fellowship (JRF)

Indian Academy of Science (IASc) Summer Research Fellowship 2007, India