Prof. Amita (Pathak) Mahanty

Profile

ami@chem.iitkgp.ac.in

B-201, IIT Campus, Kharagpur - 721302, West Bengal

Research Statement

Research in our group is focussed on the synthesis of functionalized nanostructured materials and their nanocomposites through indigenously developed, novel and simple solution phase processing techniques i.e., through “bottom-up” approach.

Nanostructured materials, by virtue of their boundary surface-determined properties, bring about novel properties (e.g., extraordinary mechanical, electric, magnetic etc.) compared to their bulk counterparts. The challenge is to use chemistry to manipulate the particulate dimensions/ morphologies of a material to accomplish the desired nanostructure or to modify / functionalize their surface through appropriate manoeuvring of the chemical composition and the processing parameters. The motivation is to study the structure/property correlations of the nanostructures for exploiting their technological benefits in the field of – catalysis, sensors, pigments, ferroelectric/ magnetic device fabrication, separation technology, biomedical applications etc. The systems of interest include: Magnetic oxides (spinel ferrites, orthoferrites, iron garnets); Structural and other mixed oxide materials (e.g., chromites, aluminates, zirconates, vanadates, molybdates, tungstates); Double & complex ferroelectric oxides with perovskite/ layered type perovskite / tetragonal tungsten bronze structures; Curved nanostructures of layered MoS2 and WS2 etc.

Our recent research-ventures, carried out in collaboration with the School of Medical Science and Technology, IIT Kharagpur has been on the development of biocompatible nanostructures/ nanocomposites for (a) fabrication of nanocarriers for targeted drug delivery for the treatment of cancer (both, in-vivo and in vitro studies) using surface functionalized magnetic nanoparticles, fluorescent carbon dots, hollow / mesoporous inorganic nanostructures; (b) spectroscopic detection of toxins (such as, hydrogen peroxide and heavy metals) using carbon-based nanocomposites; and (c) development of florescent probes for biomedical applications.

1. Synthesis of Functional Nanostructures and their Application

Publications

Journal Publications

Angana Bhattacharya, Dipanjan Samanta, Manisha Shaw, Md Abdus Salam Shaik, Rajarshi Basu, Imran Mondal, Amita Pathak*, "Sensitive Detection of Hg2+ and l-Cysteine through Optical Asymmetry-Tuned Fluorescence Switch Off-On Behavior in N-Doped Chiral Carbon Dot" ACS Applied Bio Materials, 2024

Dipanjan Samanta, Manisha Shaw, Md Abdus Salam Shaik, Rajarshi Basu, Imran Mondal, Angana Bhattacharya, and Amita Pathak*, "Chirality Cascade and Atomic-Scale Helicity in Hierarchical Chiral CuO Nanostructures" The Journal of Physical Chemistry C, 2024

Imran Mondal, Dipanjan Samanta, Md Abdus Salam Shaik, Manisha Shaw, Angana Bhattacharya, Rajarshi Basu, Amita Pathak*, "Influence of Nitrogen-Doped Carbon Dots on H• Radical-Mediated Au–H Formation in the Hydrogenation of 4-Nitrophenol Using NCDs-Au Nanohybrids" Langmuir, 2024

Nagaprasad Puvvada, Md. Abdus Salam Shaik, Dipanjan Samanta, Manisha Shaw, Imran Mondal, Rajarshi Basu, Angana Bhattachariya, Amita Pathak, "Biocompatible fluorescent carbon nanoparticles as nanocarriers for targeted delivery of tamoxifen for regression of Breast carcinoma" Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024

Suraj Konar, Shubhatam Sen and Amita Pathak, "Chiral carbon dots: a smart choice for inhibition of human serum albumin fibrillation" New Journal of Chemistry, 2024

Imran Mondal, Dipanjan Samanta, Md Abdus Salam Shaik, , Rajarshi Basu, Angana Bhattacharya, Manisha Shaw, Amita Pathak, "“Click” Chemistry Assisted Synthesis of Magnetite-CNT Nanohybrid Supported Gold Nanoparticles for Enhanced Catalytic Reduction of 4-Nitrophenol" ChemistrySelect, 2023

Manisha Shaw, Dipanjan Samanta, Md Abdus Salam Shaik, Rajarshi Basu, Debasish Das*, Amita Pathak*, "Ethanol Gas Sensors Using Semi-Hedgehog-like CuO Nanostructures: Studying the Role of Oxygen Vacancies, Unsaturated Cu-Sites, and Hole Accumulation Layer" ACS Applied Nano Material, 2023

Md Abdus SalamShaik1, DipanjanSamanta1, Ankit Kumar Sharma, Manisha Shaw, Sayan Prodhan, Rajarshi Basu, Imran Mondal, Shailab Singh, Prasanta Kumar Dutta, Amita Pathak, "White light emission from helically stacked humin-mimic based H-aggregates in heteroatom free carbon dots" Nanoscale, 2023

Rosy Rahman, Priyanka Rani, Subhadip Ghosh, Anupam Midya , Amita Pathak* *, and Tapan Kumar Nath*, "Engineering Hierarchical Self-Assembled PANI-/1T@2H MoS2 Nanostructure toward Ultrahigh Performance Supercapacitor Electrodes" ACS Applied Energy Materials, 2023

Dipanjan Samanta1, Manisha Shaw1, Md Abdus Salam Shaik1, Rajarshi Basu, Imran Mondal, Angana Bhattacharya, and Amita Pathak*, "Optical Asymmetry and Structural Complexity in Hierarchically Organized Chiral CuO Nanostructures: Insight into the Geometric and Crystallographic Effects on Cooperative Chirality" Inorganic Chemistry, 2023

Dr. Suraj Konar, Md. Abdus Salam Shaik, Dipanjan Samanta, Manisha Shaw, Rajarshi Basu, Dr. Madhusudan Kr. Mahto, Imran Mondal, Prof. Amita Pathak, "Carbon Dots as a Fluorescent Probe for Appraising Morphology-Dependent Free-Radical-Scavenging Properties of CuO Nanostructures" ChemistrySelect, 2023

Madhusudan Kr. Mahto1 , Dipanjan Samanta1, Manisha Shaw, Md Abdus Salam Shaik, Rajarshi Basu, Imran Mondal, Angana Bhattacharya, and Amita Pathak*, "Blue-Emissive Nitrogen-Doped Carbon Dots for Picric Acid Detection: Molecular Fluorescence Quenching Mechanism" ACS Applied Nano Materials, 2023

Imran Mondal, Dipanjan Samanta, Manisha Shaw, Md Abdus Salam Shaik, Madhusudan Kr Mahto, Rajarshi Basu, Angana Bhattacharya, Amita Pathak, "Pyridinic-N-rich carbon dots in IFE-based Turn-off Fluorometric detection of nerve agent Mimic– Diethyl chlorophosphate and multicolor cell imaging" Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023

Manisha Shaw, Dipanjan Samanta, Md Abdus Salam Shaik, Angana Bhattacharya, Rajarshi Basu, Imran Mondal, Amita Pathak, "Solvent-induced switching between static and dynamic fluorescence quenching of N, S Co-doped carbon dots in sensing of Crotonaldehyde: A detailed systematic study" Optical Materials, 2023

Manisha Shaw , Dipanjan Samanta, Sharmita Bera, Madhusudan Kr Mahto, Md Abdus Salam Shaik, Suraj Konar, Imran Mondal, Dibakar Dhara, and Amita Pathak*, "Cover ART @Inorganic Chemistry" Inorganic Chemistry, 2022

Manisha Shaw1, Dipanjan Samanta1, Md Abdus Salam Shaik, Angana Bhattacharya, Rajarshi Basu, Imran Mondal, Amita Pathak, "Role of Surface Oxygen Vacancies and Oxygen Species on CuO Nanostructured Surfaces in Model Catalytic Oxidation and Reductions: Insight into the Structure–Activity Relationship Toward the Performance" Inorganic Chemistry, 2022

Md Abdus SalamShaik, DipanjanSamanta, ManishaShaw, ImranMondal, RajarshiBasu, AmitaPathak, "Fluorescent N, S co-doped Carbon Dots for Tartrazine Sensing and Mechanistic Perception of their Radical Scavenging Activity" Sensors and Actuators Reports, 2022

Rosy Rahman , S. Chaudhuri, Dipanjan Samanta , A. Pathak and T. K. Nath, "Insights into the Multifunctional Applications of Strategical Co doped MoS2 Nanoflakes" Materials Advances, 2022

Rosy Rahman, Manobina Karmakar, Dipanjan Samanta, Amita Pathak,* Prasanta Kumar Datta* and Tapan Kumar Nath*, "One Order Enhancement of Charge Carrier Relaxation Rate by Tuning Structural and Optical Properties in Annealed Cobalt Doped MoS2 Nanosheets" New Journal of Chemistry, 2022

Sangeeta Tantubay , Himani Kalita, Amita Pathak, "Sensitive detection of auric and sulphide ions using hybrid silver/nitrogen-doped carbon nanoparticles" Sensors and Actuators B: Chemical, 2021

Rosy Rahman, Dipanjan Samanta, Amita Pathak* and Tapan Kumar Nath*, "Tuning of structural and optical properties with enhanced catalytic activity in chemically synthesized Co-doped MoS2 nanosheets" RSC Advances, 2021

Suraj Konar, B.N. Prashanth Kumar, Madhusudan Kr. Mahto, Dipanjan Samanta, Md Abdus Salam Shaik, Manisha Shaw, Mahitosh Mandal, Amita Pathak, "N-Doped Carbon Dot as fluorescent probe for detection of Cysteamine and multicolor cell imaging" Sensors & Actuators: B. Chemical, 2019

B. N. Prashanth Kumar, Nagaprasad Puvvada, Shashi Rajput, Siddik Sarkar, Madhusudan Kr. Mahto, Murali M. Yallapu, Amita Pathak, Luni Emdad, Swadesh K. Das, Rui L. Reis, S. C. Kundu, Paul B. Fisher and Mahitosh Mandal, "Targeting of EGFR, VEGFR2, and Akt by Engineered Dual Drug Encapsulated Mesoporous Silica–Gold Nanoclusters Sensitizes Tamoxifen-Resistant Breast Cancer" Mol. Pharmaceutics, 2018

Madhusudan Kr. Mahto, Dipanjan Samanta, Suraj Konar , Himani Kalita, and Amita Pathak, "N, S doped carbon dots—Plasmonic Au nanocomposites for visible-light photocatalytic reduction of nitroaromatics" Journal of Materials Research, 2018

Suraj Konar, Dipanjan Samanta, Subhajit Mandal, Subhayan Das, Madhusudan Kr Mahto, Manisha Shaw, Mahitosh Mandal and Amita Pathak, "Selective and sensitive detection of cinnamaldehyde by nitrogen and sulphur co-doped carbon dots: a detailed systematic study" RSC Advances, 2018

Himani Kalita, Pallabi Pal, Santanu Dhara and AmitaPathak, "Fabrication and characterization of polyvinyl alcohol/metal (Ca, Mg, Ti) doped zirconium phosphate nanocomposite films for scaffold-guided tissue engineering application" Materials Science and Engineering: C, 2017

Siddik Sarkar, Suraj Konar, Puvvada Naga Prasad, Shashi Rajput, B. N. Prashanth Kumar, Raj R. Rao, Amita Pathak, Paul B. Fisher, and Mahitosh Mandal, "Micellear Gold Nanoparticles as Delivery Vehicles for Dual Tyrosine Kinase Inhibitor ZD6474 for Metastatic Breast Cancer Treatment" Langmuir, 2017

Suraj Konar, Shubhatam Sen and Amita Pathak, "Morphological Effects of CuO Nanostructures on Fibrillation of Human Serum Albumin" J. Phys. Chem. B, 2017

H. Kalita, B.N. Prashanth Kumar, S. Tantubay, M. K. Mahto, M. Mandal and A. Pathak, "Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application" Materials Science and Engineering: C, 2016

Himani Kalita, Shashi Rajput, B. N. Prashanth Kumar, Mahitosh Mandal and Amita Pathak, "Fe3O4@zirconium phosphate core–shell nanoparticles for pH-sensitive and magnetically guided drug delivery applications" RSC Advances, 2016

Shubhatam Sen, Suraj Konar, Bodhisatwa Das, Amita Pathak, Santanu Dhara, Swagata Dasgupta and Sunando DasGupta, "Inhibition of fibrillation of human serum albumin through interaction with chitosan-based biocompatible silver nanoparticles" RSC Advances, 2016

Himani Kalita and Amita Pathak, "Preparation of Hollow TiO2 Nanospheres for Biomedical Applications" Green Chemistry and Technology Letters, 2(2), 68-73 (2016), 2016

Suraj Konar, Himani Kalita, Nagaprasad Puvvada, SangeetaTantubay, Madhusudan Kr.Mahto, Suprakash Biswas and AmitaPathak, "Shape-dependent catalytic activity of CuO nanostructures," Journal of Catalysis, 336, 11-22 (2016), 2016

S. Rajput, N. Puvvada,B. N. P. Kumar, S. Sarkar, S. Konar, R. Bharti, G. Dey, A.. Mazumdar, A. Pathak, P.B. Fisher, M. Mandal, "Overcoming Akt Induced Therapeutic Resistance in Breast Cancer through siRNA and Thymoquinone Encapsulated Multilamellar Gold Niosomes" Molecular Pharmaceutics, 12 (12) , 4214â€“422 (2015), 2015

Sangeeta Tantubay, Sourav K Mukhopadhyay, Himani Kalita, Suraj Konar, Satyahari Dey, Amita Pathak, Panchanan Pramanik, "Carboxymethylated chitosan-stabilized copper nanoparticles: A promise to contribute a potent antifungal and antibacterial agent" Journal of Nanoparticle Research, 17 (6) 1-18 (2015), 2015

Nagaprasad Puvvada, Shashi Rajput, B.N. Prashanth Kumar, Siddik Sarkar, Suraj Konar, Keith R. Brunt, Raj R. Rao, Abhijit Mazumdar, Swadesh K. Das, Ranadhir Basu, Paul B. Fisher, Mahitosh Mandal and Amita Pathak, "Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression" Scientific Reports, 5:11760, 1-15 (2015), 2015

H Kalita, S Konar, S Tantubay, MK Mahto, A Pathak, "Phase transformation in Mn-doped titania hollow spheres and their biocompatibility studies" Applied Nanoscience, 1-10 (2015), 2015

BN Prashanth Kumar, Nagaprasad P, S Rajput, S Sarkar, S K Das, L Emdad, D. Sarkar, P Venkatesan, I. Pal, G. Dey, S. Konar, K R Brunt, Raj R Rao, A. Mazumdar, S C Kundu, A Pathak, P B Fisher, M Mandal, "Sequential release of drugs from hollow manganese ferrite nanocarriers for breast cancer therapy" Journal of Materials Chemistry B,, 3 (1), 90-101. (2015), 2015

S Sen, S Konar, A Pathak, S Dasgupta, S DasGupta, "Effect of Functionalized Magnetic MnFe2O4 Nanoparticles on Fibrillation of Human Serum Albumin" The Journal of Physical Chemistry B,, 118 (40), 11667-116 (2014), 2014

S. Karthik, Nagaprasad Puvvada, B. N. Prashanth Kumar, Shashi Rajput, Amita Pathak, Mahitosh Mandal, and N. D. Pradeep Singh , "Photoresponsive coumarin-tethered multifunctional magnetic nanoparticles for release of anticancer drug" ACS Appl. Mater. Interfaces, 5(11), 5232-5238 (2013), 2013

Nagaprasad Puvvada, Shashi Rajput, B. N. Prashanth Kumar, Mahitosh Mandal and Amita Pathak , "Exploring the fluorescence switching phenomenon of curcumin encapsulated niosomes: in vitro real time monitoring of curcumin release to cancer cells" RSC Advances, 3, 2553-2557 (2013), 2013

Pravas Kumar Panigrahi and Amita Pathak , "The Growth of Bismuth Sulfide Nanorods from Spherical-Shaped Amorphous Precursor Particles under Hydrothermal Condition" Journal of Nanoparticles, Volume 2013, Article (2013), 2013

Nagaprasad Puvvada, B N Prashanth Kumar, Suraj Konar, Himani Kalita, Mahitosh Mandal and Amita Pathak , "Synthesis of biocompatible multicolor luminescent carbon dots for bioimaging applications " SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 13, 045008 (2012), 2012

Nagaprasad Puvvada, Pravas Kumar Panigrahi, Himani Kalita, Keka R. Chakraborty, Amita Pathak , "Effect of temperature on morphology of triethanolamine-assisted synthesized hydroxyapatite nanoparticles" Applied Nanoscience, Vol 2 (2012), 2012

Nagaprasad Puvvada, Dhritabrata Mandal, Pravas Kumar Panigrahi and Amita Pathak , "Aqueous route for the synthesis of magnetite nanoparticles under atmospheric air: functionalization of surface with fluorescence marker " Toxicology Research, Vol 1, pp 196 (2012), 2012

Nagaprasad Puvvada, Pravas Kumar Panigrahi, Dhritabrata Mandal and Amita Pathak, "Shape dependent peroxidase mimetic activity towards oxidation of Pyrogallol by H2O2" RSC Advances, 2, 3270-3273 (2012), 2012

Pravas Kumar Panigrahi and Amita Pathak , "A novel route for the synthesis of nanotubes and fullerene-like nanostructures of molybdenum disulfide" Materials Research Bulletin, 46 (12) 2240-224 (2011), 2011

P. Venkatesan, Nagaprasad Puvvada, Rupesh Dash, B.N. Prashanth Kumar, Devanand Sarkar, Belal Azab, Amita Pathak, Subhas C. Kundu, Paul B. Fisher, Mahitosh Mandal , "The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer" Biomaterials, 32 3794-3806 (2011), 2011

Biswas S. K., A. Sarkar, A. Pathak, and P. Pramanik, "Studies on the sensing behaviour of nanocrystalline CuGa2O4 towards hydrogen, liquefied petroleum gas and ammonia" Talanta, 81 1607â€“1612 (2010), 2010

Nagaprasad Puvvada, Pravas Kumar Panigrahi and Amita Pathak, "Room temperature synthesis of highly hemocompatible hydroxyapatite, study of their physical properties and spectroscopic correlation of particle size" Nanoscale, 2 2631â€“2638 (2010), 2010

Pravas Kumar Panigrahi and Amita Pathak , "Microwave-assisted synthesis of WS2 nanowires through tetrathiotungstate precursors" Science and Technology of Advanced Materials, 9, 045008 (2008), 2008

Soumya Kanti Biswas, Debasis Dhak, Amita Pathak, Panchanan Pramanik , "Chemical synthesis of environment-friendly nanosized yellow titanate pigments" Material Research Bulletin, 43, 665â€“675, (2008), 2008

Soumya K. Biswas, A. Pathak, N. K. Pramanik, D. Dhak, P. Pramanik , "Codoped Cr and W rutile nanosized powders obtained by pyrolysis of triethanolamine complexes" Ceramic International, 34 (8), 1875-1883 (2008), 2008

Soumya Kanti Biswas, Amita Pathak, Panchanan Pramanik, "Synthesis of Nanocrystalline KTiOPO4 Powder by Chemical Method" Journal of the American Ceramic Society, 90(4), 1071-1076 (2007), 2007

A.B. Panda, A. Pathak, P. Pramanik, "Chemical Synthesis of Nanocrystalline Strontium Bismuth Tantalate (SBT) Powders Using Tantalum Tartarate complex" Journal of American Ceramic Society, 89 [2] 737â€“739 (2006), 2006

A. Pathak, S. Mohapatra, S. Mohapatra, S.K. Biswas, D. Dhak, A. Tarafdar, P. Pramanik , "Preparation of Nanosized Mixed-Oxide Powders using Triethanolamine / Diethanolamine as Complexing Agent " American Ceramic Society Bulletin, 83 (8), 9301-9306 (2004), 2004

A. Mohanty and J. Dey , "A giant vesicle forming single tailed chiral surfactant for enantioseparation by micellar electrokinetic chromatography" J. Chem. Soc. Chem. Comm., 1384-1385 PP (2003), 2003

Projects

Synthesis of Inorganic Fullerene-type MoS2 and WS2 Nanoparticles and Study of their Lubrication Properties
Client:
PI: Dr Amita (Pathak) Mahanty | Co-Consultant(s): ISIRD, IIT Kharagpur

New Polymers and Polymer Composites : Design, Synthesis, and Advanced Applications
Client: IIT Kharagpur:One-time Seed Grant for Research Infrastructure in an area of Emerging Thrust (SGDRI)
PI: D. Dhara | Co-Consultant(s): A. Ayyappan, A.Basak, D. Dhara, A.(Pathak) Mahanty, D. Mal, T Pal, T .Pathak, S. K. Patra, C. R. Ra