Prof. Biswarup Jash

Prof. Biswarup Jash

Assistant Professor

Profile

Personal Website

Bio / CV

bjash@chem.iitkgp.ac.in

C1-183; Indian Institute of Technology Kharagpur, Kharagpur-721302

Education

<p>2009-2012&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; B.Sc. in Chemistry; <em>Ramakrishna Mission Residential College (Autonomous)</em>; Narendrapur, Kolkata.&nbsp;</p>

<p>2012-2014&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; M.Sc. in Chemistry; <em>Indian Institute of Technology</em>, Kanpur.&nbsp;</p>

<p>2014-2018&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Ph.D. Student; <em>University of M&uuml;nster,</em>&nbsp;Germany/ Ph.D. thesis title: <em>&ldquo;1H-Imidazo[4,5-f][1,10]phenanthroline as a ligand in metal-modified nucleic acids&rdquo;.&nbsp;</em>Supervisor: <strong>Dr. Jens M&uuml;ller</strong>.</p>

Experience

<p>Mar 2022-Present&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Assistant Professor; <em>Indian Institute of Technology, Kharagpur</em>, India.&nbsp;</p>

<p>Feb 2021-Mar 2022&nbsp; &nbsp; &nbsp; Postdoctoral Researcher; <em>Stanford University,</em> USA. Supervisor: <strong>Dr. Eric T Kool</strong>.</p>

<p>Aug 2018-Sept 2020&nbsp; &nbsp; &nbsp;Postdoctoral Researcher; <em>University of Stuttgart,</em> Germany. Supervisor: <strong>Dr. Dr. Clemens Richert</strong>.</p>

<p>Feb 2018-June 2018&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Postdoctoral Researcher;&nbsp;<em>WWU M&uuml;nster</em>, Germany. Supervisor: <strong>Dr. Jens M&uuml;ller</strong>.</p>

<p>&nbsp;</p>

Research Statement

As chemists, we are intensely interested in the field of nucleic acid, and value in-depth investigation of the subject and its challenges. 

We primarily focus on two topics.

G-quadruplex nucleic acid
Prebiotic chemistry

All projects typically require the involvement of synthetic organic chemistry, coordination chemistry, and nucleic acid chemistry.

For more information, Please visit our website: https://www.jashlab.org/

 

Publications

Journal Publications

B. Jash, E. T. Kool, "Conjugation of RNA via 2’-OH acylation: Mechanisms determining nucleotide reactivity" Chemical Communication 2022, 58, 3693-3696, 2022
H. S. Park, B. Jash, L. Xiao, Y. W. Jun, E. T. Kool, "Control of RNA with quinone methide reversible acylating reagents" Organic & Biomolecular Chemistry 2021,19, 8367-8376, 2021
B. Jash, P. Tremmel, D. Jovanovic, C. Richert, "Single Nucleotide Translation without Ribosomes" Nature Chemistry 2021, 13, 751-757, 2021
B. Jash, C. Richert, "Templates direct the sequence-specific anchoring of the C-terminus of peptido RNAs" Chemical Science 2020, 11, 3487-3494, 2020
B. Jash, J. Mueller, "Stable Hg(II)-mediated base pairs with a phenanthroline-derived nucleobase surrogate in antiparallel-stranded DNA" Journal of Biological Inorganic Chemistry 2020, 25, 647-654, 2020
B. Jash, J. Mueller, "A stable Zinc(II)-mediated base pair in parallel-stranded DNA duplex" Journal of Inorganic Biochemistry 2018, 186, 301-306, 2018
B. Jash, J. Mueller, "Concomitant site-specific incorporation of Silver(I) and Mercury(II) ions into a DNA duplex" Chemistry – A European Journal 2018, 24, 10636-10640, 2018
B. Jash, J. Mueller, "Stable Copper(I)-mediated base pair in DNA" Angewandte Chemie International Edition 2018, 57, 9524-9527, 2018
B. Jash, J. Mueller, "Metal-mediated base pairs: from characterization to application" Chemistry – A European Journal 2017, 23, 17166-17178, 2017
B. Jash, J. Mueller, "Application of a metal-mediated base pair to the detection of medicinally relevant single nucleotide polymorphisms" European Journal of Inorganic Chemistry 2017, 3857-3861, 2017
B. Jash, P. Scharf, N. Sandmann, C. Fonseca Guerra, D. A. Megger, J. Mueller, "A metal-mediated base pair that discriminates between the canonical pyrimidine nucleobases" Chemical Science 2017, 8, 1337-1343, 2017
B. Jash, J. Neugebauer, J. Mueller, "Enantiospecific formation of metal-mediated base pair inside a DNA duplex" Inorganica Chimica Acta 2016, 452, 181-187, 2016
P. Scharf,§ B. Jash,§ J. A. Kuriappan, M. P. Waller, J. Mueller, (§equal first author contribution), "Sequence-dependent duplex stabilization upon formation of a metal-mediated base pair" Chemistry – A European Journal 2016, 22, 295-301, 2016

Projects

Role of metal ions in the synthesis of the early form of biomolecules
Client: SRIC-IIT Kgp
PI: Biswarup Jash  |  Co-Consultant(s):
Route to find out the primitive form of enzymes and their functions in the early biochemical reactions
Client: SRG-SERB
PI: Biswarup Jash  |  Co-Consultant(s):

Awards and Recognition

1. INSPIRE Faculty Fellowship 2019
<p>by Department of Science and Technology, India</p>
2. PhD Fellowship; Muenster, Germany, 2014
<p>Issued by International Graduate School of Chemistry, Muenster, Germany</p>
3. INSPIRE Fellowship from 2009-2014
<p>Issued by Deapartment of Science and Technology</p>
4. P. C. Rakshit award for outstanding all-round performance
<p>Awarded by Ramakrishna Mission Residential College, Narendrapur, Kolkata</p>
5. D. K. Mitra award for securing 1st position in Chemistry Honors
<p>Awarded by Ramakrishna Mission Residential College, Narendrapur, Kolkata</p>
6. Important Entrance Test Qualified
<p>JAM Exam, 2012 (AIR 5); CSIR-NET Exam for JRF, 2013 (AIR 29); GATE Exam, 2014</p>

Courses Taught

CHEMISTRY OF 3d-ELEMENTS (CY20204)
CHEMISTRY LABORATORY (CY19001)
MOLECULAR STRUCTURE AND BONDING (CY21203)
ADVANCED INORGANIC LAB (CY49203)

Patents

No patents on record.

Research Group

Current Members

Debarati Bhattacharya
Debarati Bhattacharya
G-quadruplex nucleic acid
debarati@kgpian.iitkgp.ac.in
Manick Mistri
Manick Mistri
Prebiotic Chemistry
mmistri168@kgpian.iitkgp.ac.in
Nirmal Pal
Nirmal Pal
Prebiotic Chemistry
nirmalpal1416@kgpian.iitkgp.ac.in