Prof. Biswarup Jash

Prof. Biswarup Jash

Assistant Professor

Profile

Personal Website

Bio / CV

bjash@chem.iitkgp.ac.in

C1-183; Indian Institute of Technology Kharagpur, Kharagpur-721302

Education

2009-2012        B.Sc. in Chemistry; Ramakrishna Mission Residential College (Autonomous); Narendrapur, Kolkata. 

2012-2014        M.Sc. in Chemistry; Indian Institute of Technology, Kanpur. 

2014-2018        Ph.D. Student; University of Münster, Germany/ Ph.D. thesis title: “1H-Imidazo[4,5-f][1,10]phenanthroline as a ligand in metal-modified nucleic acids”. Supervisor: Dr. Jens Müller.

Experience

Mar 2022-Present         Assistant Professor; Indian Institute of Technology, Kharagpur, India. 

Feb 2021-Mar 2022      Postdoctoral Researcher; Stanford University, USA. Supervisor: Dr. Eric T Kool.

Aug 2018-Sept 2020     Postdoctoral Researcher; University of Stuttgart, Germany. Supervisor: Dr. Dr. Clemens Richert.

Feb 2018-June 2018      Postdoctoral Researcher; WWU Münster, Germany. Supervisor: Dr. Jens Müller.

 

Research Statement

As chemists, we are intensely interested in the field of nucleic acid, and value in-depth investigation of the subject and its challenges. 

We primarily focus on two topics.

G-quadruplex nucleic acid
Prebiotic chemistry

All projects typically require the involvement of synthetic organic chemistry, coordination chemistry, and nucleic acid chemistry.

For more information, Please visit our website: https://www.jashlab.org/

 

Publications

Journal Publications

B. Jash, E. T. Kool, "Conjugation of RNA via 2’-OH acylation: Mechanisms determining nucleotide reactivity" Chemical Communication 2022, 58, 3693-3696, 2022
H. S. Park, B. Jash, L. Xiao, Y. W. Jun, E. T. Kool, "Control of RNA with quinone methide reversible acylating reagents" Organic & Biomolecular Chemistry 2021,19, 8367-8376, 2021
B. Jash, P. Tremmel, D. Jovanovic, C. Richert, "Single Nucleotide Translation without Ribosomes" Nature Chemistry 2021, 13, 751-757, 2021
B. Jash, C. Richert, "Templates direct the sequence-specific anchoring of the C-terminus of peptido RNAs" Chemical Science 2020, 11, 3487-3494, 2020
B. Jash, J. Mueller, "Stable Hg(II)-mediated base pairs with a phenanthroline-derived nucleobase surrogate in antiparallel-stranded DNA" Journal of Biological Inorganic Chemistry 2020, 25, 647-654, 2020
B. Jash, J. Mueller, "A stable Zinc(II)-mediated base pair in parallel-stranded DNA duplex" Journal of Inorganic Biochemistry 2018, 186, 301-306, 2018
B. Jash, J. Mueller, "Concomitant site-specific incorporation of Silver(I) and Mercury(II) ions into a DNA duplex" Chemistry – A European Journal 2018, 24, 10636-10640, 2018
B. Jash, J. Mueller, "Stable Copper(I)-mediated base pair in DNA" Angewandte Chemie International Edition 2018, 57, 9524-9527, 2018
B. Jash, J. Mueller, "Metal-mediated base pairs: from characterization to application" Chemistry – A European Journal 2017, 23, 17166-17178, 2017
B. Jash, J. Mueller, "Application of a metal-mediated base pair to the detection of medicinally relevant single nucleotide polymorphisms" European Journal of Inorganic Chemistry 2017, 3857-3861, 2017
B. Jash, P. Scharf, N. Sandmann, C. Fonseca Guerra, D. A. Megger, J. Mueller, "A metal-mediated base pair that discriminates between the canonical pyrimidine nucleobases" Chemical Science 2017, 8, 1337-1343, 2017
B. Jash, J. Neugebauer, J. Mueller, "Enantiospecific formation of metal-mediated base pair inside a DNA duplex" Inorganica Chimica Acta 2016, 452, 181-187, 2016
P. Scharf,§ B. Jash,§ J. A. Kuriappan, M. P. Waller, J. Mueller, (§equal first author contribution), "Sequence-dependent duplex stabilization upon formation of a metal-mediated base pair" Chemistry – A European Journal 2016, 22, 295-301, 2016

Projects

Role of metal ions in the synthesis of the early form of biomolecules
Client: SRIC-IIT Kgp
PI: Biswarup Jash  |  Co-Consultant(s):
Route to find out the primitive form of enzymes and their functions in the early biochemical reactions
Client: SRG-SERB
PI: Biswarup Jash  |  Co-Consultant(s):

Awards and Recognition

1. INSPIRE Faculty Fellowship 2019

by Department of Science and Technology, India

2. PhD Fellowship; Muenster, Germany, 2014

Issued by International Graduate School of Chemistry, Muenster, Germany

3. INSPIRE Fellowship from 2009-2014

Issued by Deapartment of Science and Technology

4. P. C. Rakshit award for outstanding all-round performance

Awarded by Ramakrishna Mission Residential College, Narendrapur, Kolkata

5. D. K. Mitra award for securing 1st position in Chemistry Honors

Awarded by Ramakrishna Mission Residential College, Narendrapur, Kolkata

6. Important Entrance Test Qualified

JAM Exam, 2012 (AIR 5); CSIR-NET Exam for JRF, 2013 (AIR 29); GATE Exam, 2014

Courses Taught

CHEMISTRY OF 3d-ELEMENTS (CY20204)
CHEMISTRY LABORATORY (CY19001)
MOLECULAR STRUCTURE AND BONDING (CY21203)
ADVANCED INORGANIC LAB (CY49203)

Patents

No patents on record.

Research Group

Current Members

Debarati Bhattacharya
Debarati Bhattacharya
G-quadruplex nucleic acid
debarati@kgpian.iitkgp.ac.in
Manick Mistri
Manick Mistri
Prebiotic Chemistry
mmistri168@kgpian.iitkgp.ac.in
Nirmal Pal
Nirmal Pal
Prebiotic Chemistry
nirmalpal1416@kgpian.iitkgp.ac.in