ganesh.v@chem.iitkgp.ac.in
3222283318 (Office)
Room No. 704, 7th Floor, JCG-PCR Building, Department of Chemistry, Indian Institute of Technology Kharagpur-721302, WB, INDIA
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<p><strong>2007 – 2012: Ph. D. (Integrated),</strong> Indian Institute of Science (IISc) Bangalore.</p>
<p><strong>2004–2007: M.S. (Integrated Ph. D.) </strong>Indian Institute of Science (IISc), Bangalore, India.</p>
<p><strong>2001–2004: B.Sc. Chemistry </strong>Bharathidasan University, Tiruchirappalli, India</p>
<p><strong>Aug'18 - Present: </strong>Assistant Professor Grade I, IIT Kharagpur, West Bengal, India</p>
<p><strong>2018 - 2018: </strong>Postdoctoral Research Associate, University of Bristol, UK</p>
<p><strong>2016 - 2018: </strong>Newton International Fellow, University of Bristol, UK</p>
<p><strong>2013 - 2015:</strong> JSPS Fellow, Institute of Microbial Chemistry, Tokyo, Japan.</p>
<p><strong>2009:</strong> Short-term Exchange Researcher, University of Paris–11</p>
Our main focus is on Organic Synthesis, developing new approaches to molecular skeletons, and building complexity rapidly yet selectively. In our laboratory, we develop such transformations catalyzed by metal salts and organocatalysts to achieve the above goals. Our interests include element-element coupling/addition reactions (element being -B, -Si, -F, -C, -N, -X, etc.), Redox chemistry involving radicals, and so on.
The approach to complex molecular skeletons has transformed with a growing arsenal of efficient synthetic methodologies. Metals play an important role in this due to their diverse reactivity at their various oxidation states. Our group will focus on developing new, interesting multifunctionalization reactions utilizing this diversity. Some of the major areas that we currently focus on are:
1. Catalysis with Reactive Intermediates like Arynes etc.
2. Tandem Catalysis.
3. Hydrogen-Borrowing Catalysis.
4. Metal-Mediated Introduction of Main Group Functionalities.
Nickel(0) catalyzed cycloaddition reactions offer a versatile and efficient way to construct complex organic molecules, showcasing the power of transition metal catalysis in modern synthetic chemistry. Our interest lies in making this powerful chemistry more user-friendly and widely applicable.
We demonstrated the potential of Ni(COD)(DQ), a bench-stable Ni(0) complex, as a catalyst for the reductive coupling of aldehydes with alkynes and ynamides, providing silylated allyl alcohols with excellent yields and regioselectivities. Mass spectrometric identification of the intermediates and DFT studies supported the proposed mechanism. The methodology demonstrated a modular approach for in situ Ni(NHC)(EDO) complex generation, enabling faster ligand screening for enantioselective catalysis. The exceptional stability and catalytic activity of Ni(COD)(DQ) on the bench for over six months offer the potential for user-friendly Ni(0) chemistry.
We are interested in introducing Main group functionalities that are challenging on various systems. We employ transition metals and organocatalysts to achieve such transformations.
Our interest was in developing the protoboration of 1,3-diynes as a platform for the iterative functionalization of various groups on enynes and dienes. An operationally simple, regioselective protoboration of 1,3-diynes using a mixed diboron reagent and Cu(I)/phosphine catalyst provided enynylboronates and 1,4-diboryl-1,3-dienes in good yields. The iterative coupling capabilities of the products have been demonstrated along with other downstream transformations offering a range of value-added skeletons.
We use the versatility and commercial availability of a large number of phosphorus compounds towards the introduction of main-group elements in organic substrates to achieve our larger goal of simultaneous multifunctionalizations.
We disclosed an operationally simple route to delta-valerolactones through an organophosphorus-catalyzed borylative ring-opening/allylation of vinylcyclopropanes providing delta-hydroxy esters stereoselectively. The delta-hydroxy esters were lactonized to obtain densely substituted delta-valerolactones. The present methodology exhibited enhanced functional group tolerance compared to the existing metal-mediated methods.
The aromaticity of cyclic systems other than six-membered ones shows interesting molecular and optoelectric properties. We have contributed to the understanding of their mechanism of action using computational and experimental techniques.
No patents on record.
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