Prof. Joykrishna Dey

Professor and Head




Profile


Personal Website
joydey@chem.iitkgp.ac.in
A-123, IIT Campus, Kharagpur - 721302, West Bengal


Research Statement


A major area of our research is concerned with the physicochemical properties and self-assemblies of synthetic surfactants, especially chiral surfactants. With a wide range of techniques available it is natural that we cover a wide range of problems. My group is interested in how the molecular geometry affects the association properties of ionic surfactants and surfactant mixtures in aqueous and saline solutions. My group has developed some single-chain chiral surfactants that form vesicles at relatively low concentrations.
One of the areas my group currently focusing attention on is drug and gene delivery using stimuli-responsive (pH, temperature, etc.) vesicles and hydrogels. Our aim is to prepare stable unilamellar vesicles and hydrogels of amphiphilic molecules that can be used for drug/gene delivery, formulations of health-care products, and water pollution control. We have developed some responsive hydrogel formed by amino acid based chiral surfactants. My group has also discovered molecules that gel edible, as well as mineral oils.
In recent years, increasing environmental pressure to utilize safer, "greener" working practices has resulted in a dramatic expansion in the use of such water-soluble/dispersible systems in industrial processes. Water-soluble polymers that exhibit "smart" behavior (i.e. which have the ability to change their conformation in response to an external stimulus such as temperature or pH) are of particular interest as they can be used as injectable delivery systems. We have developed some pH- and redox-sensitive polymeric micelles and vesicles for delivery of anticancer drugs.
Since my group is dedicated to developing biodegradable and biocompatible drug delivery systems, a sizable part of our research involves synthesis and characterization of small molecules and polymers. Therefore, all chemists (Physical, Organic and Inorganic) are welcome to my group. I believe my group members get a complete training in Chemistry which enable them pursue independent research after the Ph.D. program.


Projects



‘HIT-TB’: Host-targeted Immunomodulatory Therapy for Tuberculosis using Bi-functional pro-drug constituted, drug loaded, surface functionalized nanocapsules
Client :   DST
Consultant :   SOMDEB BOSE DASGUPTA
Co-Consultant(s) :   JOYKRISHNA DEY

A Value Chain on Aloe Vera Processing.
Client :   ICAR, NAIP
Consultant :   P. P. Srivastav
Co-Consultant(s) :   JOYKRISHNA DEY

Evaluation of Potential Applications in Drug Delivery of Some Novel pH-Responsive, Biocompatible, and Biodegradable Hydrophobically Modified Polymers
Client :   DST
Consultant :   JOYKRISHNA DEY
Co-Consultant(s) :   

• Interactions between Water-Soluble Hydrophobically Modified Polymers and Surfactants: Rheology, Fluorescence Probe, and Calorimetric Studies
Client :   BRNS, DAE
Consultant :   JOYKRISHNA DEY
Co-Consultant(s) :   

Preparation of Stable Vesicles of Catanionic Surfactants. Characterization by Surface Tension, Fluorescence Probe, Light Scattering, and Microscopic Techniques
Client :   DST
Consultant :   JOYKRISHNA DEY
Co-Consultant(s) :   

Enantioseparation of Drugs and Small Organic Molecules by Electrokinetic Capillary Chromatography Using Vesicles as Pseudo-stationary Phase
Client :   CSIR
Consultant :   JOYKRISHNA DEY
Co-Consultant(s) :   

Interactions of Water-soluble Hydrophobically Modified Polymers with Surfactants: Fluorescence Probe and Light Scattering Studies
Client :   MHRD
Consultant :   JOYKRISHNA DEY
Co-Consultant(s) :   

Enantiomeric Separation of Chiral Drugs by Micellar Electrokinetic Chromatography
Client :   DST
Consultant :   JOYKRISHNA DEY
Co-Consultant(s) :   

Fluorescence Probe Studies of the Structure, Aggregation Mechanism of Chiral Polysoaps and Block Ionomers in Solution
Client :   CSIR
Consultant :   JOYKRISHNA DEY
Co-Consultant(s) :   

Enantiomeric Separation of Chiral Drugs by Micellar Electrokinetic Chromatography using dendrimers
Client :   ISIRD, IITKgp
Consultant :   JOYKRISHNA DEY
Co-Consultant(s) :   


Awards and Recognition


  1) Research Fellowship, IIT Kanpur (1986-1991)

  2) Research Fellowship, University Grants Commission, Government of India, 1985

  3) National Scholarship, Ministry of Education, Government of India (1982-1984)


Courses Taught


  CHEMISTRY (CY11001)

  CHEMISTRY LABORATORY (CY19001)

  COLLOIDS AND DRUG DELIVERY (CY61042)

  PHYSICAL CHEMISTRY LAB I (CY29001)

  BIOPHYSICAL CHEMISTRY (CY60004)

  MOLECULAR THERMODYNAMICS (CY41012)

  PHYSICAL CHEMISTRY LAB II (CY39001)

  PREPARATORY PHYSICAL CHEMISTRY LAB (CY00000)

  SPECTROSCOPY II (CY51001)

  COLLOIDS AND SURFACE CHEMISTRY (CY60015)

  INSTRUMENTAL METHODS OF ANALYSIS (CY43003, CY43017)

  SYMMETRY SPECTROSCOPY AND REACTION DYNAMICS (CY40008)

  MACROMOLECULES AND COLLOIDS (CY31002)

  POLYMER CHEMISTRY (CY50103)

  PREPARATORY CHEMISTRY (CY00002)


Patents


  Amino Acid Derived Low-molecular Mass Gelators and Uses Thereof(2016) File in India

  AMINO ACID DERIVED LOW MOLECULAR MASS GELATOR AND USES THEREOF (Patent No : 421265)(2023) Accept in India


Research Area



1) Self-Assembly of Surfactants and Polymers
Download Research File
2) Molecular Gels
Download Research File
3) Energetics of Protein/Polymer-Surfactant Interactions
Download Research File
4) Colloidal Systems for Drug/Gene Delivery
Download Research File

Group Members


  Deepnath Bajani
Topic: Development of stable nanoemulsion for drug delivery application
Email: bajanid13@gmail.com

  Homen Dahal
Topic: Synthesis, Self-assembly, and In-Vitro Studies of Cationic Gemini
Email: rishom95@gmail.com

  Pabitra Mondal
Topic: Self-Assembly, Interactions with DNA, and in vitro Studies by Cationic Bolaamphiphiles
Email: pabitramondal149@gmail.com

  Swagata Patra
Topic: Development of solid lipid nanoparticles (SLN) based drug delivery systems
Email: swagata1012@gmail.com


Group Alumni


  Amrita Pal
Topic: Thermoresponsive Organogels of Amino Acid Based Amphiphiles: Effect of Chirality, Hydrogen Bonding and Hydrocarbon Chain Length
Email: apal9@asu.edu

  Arjun Ghosh
Topic: Physicochemical Characterization, Self-Assembly Formation and Enantioselectivity of N-(2-Hydroxyalkyl)-L-amino Acid Amphiphiles
Email: arjun2003@gmail.com

  Ashok Mohanty
Topic: Vesicle-forming Single-tailed L-amino Acid-derived Surfactants as Chiral Selectors for Enantiomeric Separations by Capillary Electrophoresis
Email: akm@nmlindia.org

  Dibyendu Khatua
Topic: Novel Anionic and Cationic Surfactants and Surfactant Mixtures: Self-organization Studies, and Applications in Enantiomeric Separations by Capillary Electrophoresis
Email: dibyendu_iitkgp@hotmail.com

  Partha Laskar
Topic: Self-assembled Nanostructures of Novel PEG Based Stimuli-sensitive Amphiphilic Random Copolymers as Drug Delivery Systems
Email: laskarpartha@gmail.com

  Pnanabesh Dutta
Topic: Amino Acid and Amine Based Polymeric Drug Carriers: Characterization, in-Vitro Biological Evaluation, Solubilization and Release of Study
Email: pranabesh123@gmail.com

  Rati Ranjan Nayak
Topic: Self-assembly of amino acid based amphiphilic polymers
Email: rrnayak@iict.res.in

  Rita Das Mahapatra
Topic: Synthesis and Gelation Behavior of Low-Molecular-Mass Gelators: Structure-Property Relationship Studies
Email: ritasona2389@gmail.com

  Rita Ghosh
Topic: Molecular Self-assembly Study of PEG Based Unconventional Amphiphiles in Water at Room Temperature
Email: rita.ghosh476@gmail.com

  Sampad Ghosh
Topic: Interaction of Cationic and Anionic Surfactants: Preparation of pH-Responsive Stable Vesicles for Drug Delivery Applications
Email: sampad.iit@gmail.com

  Saurabh Shrivastav
Topic: Interactions of Water-soluble Hydrophobically Modified Polyelectrolytes with Ionic Surfactants of Similar and Opposite Charge
Email: nic.saurabh@gmail.com

  Subhajit Ghosh
Topic: Interaction of Serum Albumins and Pepsin with Amino Acid-derived Ionic Surfactants: Spectroscopic and Calorimetric Studiies
Email: shubh.orgchem@gmail.com

  Sumita Roy
Topic: Spontaneous Vesicle Formation by Some Selected Chiral Amino Acid-derived Single-chain Polymerizable Surfactants and Polysoaps in Water: Synthesis, Characterization and Self-organization Studies
Email: rsumita4@yahoo.co.in

  Trilochan Patra
Topic: Self-Organization of Some Novel Single-chain Biocompatible Amphiphiles in Aqueous and Non-aqueous Media
Email: trilochan.iit@gmail.com