Prof. Kiran Ramakant Gore

Assistant Professor




Profile


Bio Stats
kiran@chem.iitkgp.ac.in
9004466305(office)
Room 703, 7th Floor - Tower A, JCG-PCR Building, Department of Chemistry, Indian Institute of Technology Kharagpur West Bengal, 721302 Ph (office): +91-3222-304610; Internal (IIT KGP): 84610

Education


  1. Ph.D. in Bio-Organic Chemistry, Indian Institute of Technology Bombay, Supervisior: Prof. Dr. Pradeepkumar, P. I.
  2. M. Sc. in Organic Chemistry, Ahmednagar College, University of Pune, Pune (2nd rank)
  3. B. Sc. in Chemistry, Ahmednagar College, University of Pune, Pune (1st rank)

Experience


  1. DST Inspire Faculty, Department of Chemistry, University of Mumbai (Oct-2015 to Sept-2019).
  2. Tutor at SRSI Program, Kings Abdulla University Science and Technology, Saudi Arabia (June-2019 to Aug-2019)
  3. Tutor at SRSI Program, Kings Abdulla University Science and Technology, Saudi Arabia (June-2018 to Aug-2018).
  4. Group Principal Scientist, Innovassynth Technologies, Khopoli, Mumbai, Maharashtra (Mar-2015 to Oct 2015).
  5. Postdoctoral Research Associate, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany (Oct-2013 to Jan-2015).
  6. Work Experience as Group Principal Scientist with Innovassynth Technologies, Khopoli, Maharashtra (Mar-2015 to Oct-2015).
  7. Teaching Assistantship at Indian Institute of Technology Bombay, Tutor for under-graduate courses CH-103 (Organic Chemistry), CH-117L (General Chemistry Laboratory) (Jan 2009-Jun 2010).
  8. Work experience at Ranbaxy Research Lab (New Drug Discovery and Research Department) as Trainee Chemist. (Jun 2007-Dec 2007).


Research Statement


Our lab work at the interface of organic synthesis and chemical biology. We are interested in the synthesis of chemically modified oligonucleotides (ASOs, siRNAs, aptamer, etc.) and testing their biochemical properties. We synthesize chemically modified oligonucleotides to improve stability, cellular uptake, and potency in therapeutic applications. Few projects are in the pipeline, such as synthesis and applications of fluorescent nucleosides to study nucleic acid interactions, targeted delivery of siRNAs, etc. We are also involved in the development of turn-on fluorescent probes for the detection of biologically important molecules such as cyanide, biological thiols, heavy metals, etc. In the area of synthetic chemistry, we are developing new methodologies in the synthesis of chemically modified nucleosides, developing optical probes, etc.


Projects



Synthesis and in vivo Applications of Modified Small Interfering RNAs
Client :   DST-INSPIRE, Government of India
Consultant :   Kiran Gore
Co-Consultant(s) :   


Awards and Recognition


  1) DST-INSPIRE Faculty Award (2015-2020)

  2) Max-Planck Postdoctoral Fellowship (2013-2015)

  3) Junior Research Fellowship (CSIR-UGC 2007)

  4) Dr. M. V. Vaidya Award (B.Sc.)

  5) Avatar Meherbaba P.P.C. Trust Merit scholarship (1998 to 2007)


Courses Taught


No Course Added Yet!

Patents


  Synthesis of N2-furfuryl deoxyguanosine phosphoramidite and modified oligonucleotides. Gore, K. R.; Nair, D. T.; Pradeepkumar, P. I. (Granted, Patent Number 295309)(2018) Accept in India

  Novel Silylated HBI Analog for Rapid, Selective, and Sensitive Detection of Cyanide in Water and Living Cells. Gore, K. R. Lavanya L. Mittapelli, Abhishek L. Mirajkar, Ganesh N. Nawale (Application number 201821004548)(2018) File in India

  Highly Selective Detection and Discrimination of H2S over Cysteine Based Upon Novel Acryloyl GFP Chromophore Analog. Gore, K. R. Lavanya L. Mittapelli, Ganesh N. Nawale (Application number 201821031531)(2018) File in India


Research Area



1) Research
Download Research File

Research Interests

Our lab work at the interface of organic synthesis and chemical biology. We are interested in the synthesis of chemically modified oligonucleotides (ASOs, siRNAs, aptamer, etc.) and testing their biochemical properties. We synthesize chemically modified oligonucleotides to improve stability, cellular uptake, and potency in therapeutic applications. Few projects are in the pipeline, such as synthesis and applications of fluorescent nucleosides to study nucleic acid interactions, targeted delivery of siRNAs, etc. We are also involved in the development of turn-on fluorescent probes for the detection of biologically important molecules such as cyanide, biological thiols, heavy metals, etc. In the area of synthetic chemistry, we are developing new methodologies in the synthesis of chemically modified nucleosides, developing optical probes, etc.


Group Members


  Dola Dev
Topic: Protein-chromophore-based fluorescent sensors for detection of biologically significant molecules
Email: doladev@chem.iitkgp.ac.in

  Sumit gangopadhyay
Topic: Chemically modified therapeutic nucleic acids
Email: sumitganguly090@chem.iitkgp.ac.in


Group Alumni