Profile
Personal Website
rambabu@chem.iitkgp.ac.in
9606623712 (Office)
Department of Chemistry, High-pressure building (HP101), IIT Kharagpur, Kharagpur, West Bengal - 721302, India
Education
<p>Bachelor of Science: 2004-07, Andhra University, Visakhapatnam, India</p>
<p>Master of Sciecne: 2007-09, Adikavi Nannaya University, Rajahmundry, India</p>
<p>Ph. D: 2010-15 in Organo catalysis and enantioselective total synthesis, CSIR-National Chemical Laboratory, Pune India (PI: Dr. Arumugam Sudalai)</p>
Experience
<p>2015-16: Senior Research Assistant, Hong Kong Baptist University, Hong Kong (PI: Prof. Li Min).</p>
<p>2016-17: Post-doctoral research fellow, Nanyang Technological University, Singapore (PI: Prof. Robin Chi)</p>
<p>2017-22: Post-doctoral research fellow, Weizmann Institute of Science, Israel (PI: Prof. Dr. Nir London)</p>
<p>2023-24: Team Lead, Aurigene Pharmaceutical Services Limited, Bengaluru, India.</p>
Research Statement
Our lab is dedicated to developing novel methods for drug discovery. We work in organic synthesis and chemical biology. Our key focus areas include:
- Design and synthesis of novel covalent inhibitors for protein targets in cancer and neurodegenerative diseases.
- Design and synthesis of new electrophilic warheads to enhance the potency and selectivity of covalent inhibitors.
- Development of novel small molecule degraders, including molecular glues and PROTACs.
- Novel chemistry techniques for chemical biology applications, such as proteomics, activity-based protein profiling (ABPP), turn-on fluorescent probes, prodrugs, cellular labelling with small molecule probes, live cell imaging, protein degradation kinetics, high-throughput screening assay development, and covalent docking.
1. Positions Available
<p><strong>PhD Positions Available in Medicinal Chemistry Research Group</strong></p>
<p>We offer multiple PhD positions in my research group at the Indian Institute of Technology, Kharagpur. Highly motivated individuals with a keen interest in organic synthesis and medicinal chemistry, particularly in covalent inhibitors and PROTACs, are encouraged to apply.</p>
<p>For inquiries, please contact Dr. Rambabu Reddi at <strong>rambabu@chem.iitkgp.ac.in</strong>.</p>
<p>Candidates with CSIR-NET, JRF, GATE, or INSPIRE Fellowships are encouraged to apply directly through the online PhD portal: <a href="https://www.iitkgp.ac.in/phd-admission" target="_new">IIT-KGP PhD Admissions</a>.</p>
<p><strong>Post-doctoral positions</strong></p>
<p>Prospective candidates interested in external post-doctoral fellowships are also welcome to contact Dr. Reddi directly.</p>
<p><strong>Master Project / Thesis:</strong></p>
<p>Highly motivated students from our institute with excellent academic backgrounds are encouraged to approach Dr. Rambabu Reddi to pursue their master's thesis work in our laboratory.</p>
<p><strong>Summer Internship:</strong></p>
<p>Currently we don't have any positions.</p>
Publications
Journal Publications
, "For Full list of publications see" https://scholar.google.com.hk/citations?user=qBIuCfIAAAAJ&hl=en, 2024
Rambabu N. Reddi*, Adi Rogel, Ronen Gabizon, Dattatraya Gautam Rawale, Battu Harish, Shir Marom, Barr Tivon, Yamit Shorer Arbel, Neta Gurwicz, Roni Oren, Keren David, Jingjing Liu, Shirly Duberstein, Maxim Itkin, Sergey Malitsky, Haim Barr, Ben-Zion Katz, Yair Herishanu, Idit Shachar, Ziv Shulman, and Nir London*, "Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry" J. Am. Chem. Soc., 2023, 145, 6, 3346-3360 (as a first and co-corresponding author). https://doi.org/10.1021/jacs.2c08853, IF = 16.38., 2023
Rambabu N Reddi, Efrat Resnick, Adi Rogel, Boddu Venkateswara Rao, Ronen Gabizon, Kim Goldenberg, Neta Gurwicz, Daniel Zaidman, Alexander Plotnikov, Haim Barr, Ziv Shulman, Nir London, "Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry" J. Am. Chem. Soc., 2021, 143 (13), 4979-4992. DOI: 10.1021/jacs.0c10644. IF = 16.38., 2021
Rambabu N. Reddi, # Adi Rogel,# Efrat Resnick, Ronen Gabizon, Pragati Kishore Prasad, Neta Gurwicz, Haim Barr, Ziv Shulman, Nir London*,, "Site-Specific Labelling of Endogenous Proteins Using CoLDR Chemistry" J. Am. Chem. Soc., 2021, 143, 48, 20095–20108. https://doi.org/10.1021/jacs.1c06167, IF = 16.38, 2021
Projects
No projects on record.
Awards and Recognition
1. Outstanding Post-doctoral research fellow award-2023
<p>https://www.weizmann.ac.il/feinberg/postdocs/postdoc-fellowships/postdoctoral-prizes-fgs</p>
2. Senior post-doctoral research fellowship in Weizmann Institute of Science from 15 July 2020-15 July 2022.
3. Rising Tide Fellowship from the Rising Tide Foundation on 1st November 2017 for one year.
4. NCL-RF “Agnimitra” Best poster award in CSIR-NCL-Science day on 25th February, 2015.
5. NCL-RF NANAI NATU award for best published research in 2016, CSIR-NCL Organic Chemistry Department.
6. Junior Research Fellowship (2010-2012) awarded by CSIR-NET (113 Rank) in Chemistry in June 2009 followed by Senior Research Fellowship.
7. Qualified Graduate Aptitude Test in Engineering (GATE) in Chemistry in February 2009.
Courses Taught
DRUG DESIGN AND SYNTHESIS (CY61213)
Patents
Methacrylamide protein binders and uses thereof. Rambabu N. Reddi, Efrat Resnick, Adi Rogel, Nir London (patent number: WO2022137240A1 and IL279736B) Patent granted and license was sold to “Monte Rosa Therapeutics”. https://www.yedarnd.com/ (2021)
— File in US
Sulfamate modulators of pin1 activity and uses thereof (2023)
— File in India
A method for developing cysteine and lysine targeted covalent peptide and protein reagents (2024)
— File in India
One step process for regio selective synthesis of ?-acyloxy carbonyls (2017)
— Accept in India
Research Group
Current Members
Arnab Das
Ligand directed drug delivery-Computational study
arnabdaschem@kgpian.iitkgp.ac.in
Subhabrat Panda
Novel electrophiles for covalent inhibitor design
subhabratpanda5g@gmail.com
