Dr. Rambabu Reddi
Assistant Professor
Profile
Personal Website
rambabu@chem.iitkgp.ac.in
9606623712(office)
Department of Chemistry, High-pressure building (HP101), IIT Kharagpur, Kharagpur, West Bengal - 721302, India
Education
Bachelor of Science: 2004-07, Andhra University, Visakhapatnam, India
Master of Sciecne: 2007-09, Adikavi Nannaya University, Rajahmundry, India
Ph. D: 2010-15 in Organo catalysis and enantioselective total synthesis, CSIR-National Chemical Laboratory, Pune India (PI: Dr. Arumugam Sudalai)
Experience
2015-16: Senior Research Assistant, Hong Kong Baptist University, Hong Kong (PI: Prof. Li Min).
2016-17: Post-doctoral research fellow, Nanyang Technological University, Singapore (PI: Prof. Robin Chi)
2017-22: Post-doctoral research fellow, Weizmann Institute of Science, Israel (PI: Prof. Dr. Nir London)
2023-24: Team Lead, Aurigene Pharmaceutical Services Limited, Bengaluru, India.
Research Statement
Our lab is dedicated to developing novel methods for drug discovery. We work in organic synthesis and chemical biology. Our key focus areas include:
- Design and synthesis of novel covalent inhibitors for protein targets in cancer and neurodegenerative diseases.
- Design and synthesis of new electrophilic warheads to enhance the potency and selectivity of covalent inhibitors.
- Development of novel small molecule degraders, including molecular glues and PROTACs.
- Novel chemistry techniques for chemical biology applications, such as proteomics, activity-based protein profiling (ABPP), turn-on fluorescent probes, prodrugs, cellular labelling with small molecule probes, live cell imaging, protein degradation kinetics, high-throughput screening assay development, and covalent docking.
Projects
Awards and Recognition
1) Outstanding Post-doctoral research fellow award-2023
https://www.weizmann.ac.il/feinberg/postdocs/postdoc-fellowships/postdoctoral-prizes-fgs
2) Senior post-doctoral research fellowship in Weizmann Institute of Science from 15 July 2020-15 July 2022.
3) Rising Tide Fellowship from the Rising Tide Foundation on 1st November 2017 for one year.
4) NCL-RF “Agnimitra” Best poster award in CSIR-NCL-Science day on 25th February, 2015.
5) NCL-RF NANAI NATU award for best published research in 2016, CSIR-NCL Organic Chemistry Department.
6) Junior Research Fellowship (2010-2012) awarded by CSIR-NET (113 Rank) in Chemistry in June 2009 followed by Senior Research Fellowship.
7) Qualified Graduate Aptitude Test in Engineering (GATE) in Chemistry in February 2009.
Courses Taught
DRUG DESIGN AND SYNTHESIS (CY61213)
Patents
Methacrylamide protein binders and uses thereof. Rambabu N. Reddi, Efrat Resnick, Adi Rogel, Nir London (patent number: WO2022137240A1 and IL279736B) Patent granted and license was sold to “Monte Rosa Therapeutics”. https://www.yedarnd.com/(2021) File in US
Sulfamate modulators of pin1 activity and uses thereof(2023) File in India
A method for developing cysteine and lysine targeted covalent peptide and protein reagents(2024) File in India
One step process for regio selective synthesis of ?-acyloxy carbonyls(2017) Accept in India
Research Area
Download Research File
PhD Positions Available in Medicinal Chemistry Research Group
We offer multiple PhD positions in my research group at the Indian Institute of Technology, Kharagpur. Highly motivated individuals with a keen interest in organic synthesis and medicinal chemistry, particularly in covalent inhibitors and PROTACs, are encouraged to apply.
For inquiries, please contact Dr. Rambabu Reddi at rambabu@chem.iitkgp.ac.in.
Candidates with CSIR-NET, JRF, GATE, or INSPIRE Fellowships are encouraged to apply directly through the online PhD portal: IIT-KGP PhD Admissions.
Post-doctoral positions
Prospective candidates interested in external post-doctoral fellowships are also welcome to contact Dr. Reddi directly.
Master Project / Thesis:
Highly motivated students from our institute with excellent academic backgrounds are encouraged to approach Dr. Rambabu Reddi to pursue their master's thesis work in our laboratory.
Summer Internship:
Currently we don't have any positions.
Group Members
Arnab Das
Topic: Ligand directed drug delivery-Computational study
Email: arnabdaschem@kgpian.iitkgp.ac.in
Subhabrat Panda
Topic: Novel electrophiles for covalent inhibitor design
Email: subhabratpanda5g@gmail.com