Prof. Samik Nanda

Prof. Samik Nanda

Professor

Profile

Personal Website

snanda@chem.iitkgp.ac.in

B-101, IIT Campus, Kharagpur - 721302, West Bengal

Research Statement

Total synthesis of natural products is the most challenging and intriguing area of research in the chemical science related disciplines. In the early 20th century, the field of synthetic organic chemistry, while established in many respects, was to continue a sharp path of progress and advancement for over a century to reach the level of power and sophistication that it possesses today. This is a unique tool for accessing new chemical entities with great biological potential, which seems to be impossible to access from natural sources due to its scarce availability. In our group we focus on the total synthesis of structurally and architecturally complex natural products. The selection of our target molecules is mainly based on strategy driven approach.

1. Synthetic Organic Chemistry

Publications

Journal Publications

Chakraborty, J and Nanda, S., "Asymmetric total synthesis of paecilomycin C through intramolecular nucleophilic opening of an epoxide." Org. Biomol. Chem, 17, 7369-7379, 2019
Acharyya, R.; Rej, R.; Nanda, S. ?, "Exploration of Ring Rearrangement Metathesis (RRM) Reaction: A General and Flexible Approach for the Rapid Construction of [5,n] fused bicyclic systems en-route to linear triquinanes. " J. Org. Chem. 2018, 83, 2087-2103., 2018
Halder, J.; Das, D.; Nanda, S. , "Distinctive transformation based diversity oriented synthesis of small ring carbocyles and heterocycles from biocatalytically derived enantiopure alpha-substituted-beta-hydroxyesters " Org. Biomol. Chem. 2018, 16, 2549-2575., 2018
Acharyya. R and Nanda, S., "Asymmetric Total Synthesis of Naturally Occurring Spirocyclic Tetranorsesquiterpenoid Lanceolactone A. " Org. Biomol. Chem., 2018,16, 5027-5035, 2018
Kumar, R.; Halder, J.; Nanda, S., "Asymmetric total synthesis of (R)-alpha-cuparenone, (S)-cuparene and formal synthesis of (R)-beta-cuparenone through Meinwald rearrangement and ring closing metathesis (RCM) reaction." Tetrahedron, 2017, 73, 809-818, 2017
Pal, P.; Nanda, S. , "Asymmetric Synthesis of Ramariolides A and C through Bimetallic Cascade Cyclization and Z–E Isomerization Reaction." Org. Lett, 2017, 19, 1164-1167. , 2017
Pal, P.; Chakraborty, J.; Mali, A.; Nanda, S. , "Asymmetric total synthesis of paecilomycin F, cochliomycin C, zeaenol, 5-bromo-zeaenol and 3,5-dibromo-zeaenol by Heck coupling and late stage macrolactonization approach. " Tetrahedron, 2016, 72, 2336-2348, 2016
Kumar, R.; Rej, R. K.; Halder, J.; Mandal. H.; Nanda, S. , "Enantiopure hydroxymethylated cycloalkenols as privileged small molecular multifunctional scaffolds for the asymmetric synthesis of carbocycles. " Tetrahedron: Asymmetry, 2016, 27, 498-512., 2016
Rej, R. K.; Acharyya, R. K.; Nanda, S. , "Asymmetric synthesis of dihydroartemisinic acid through intramolecular stetter reaction" Tetrahedron, 2016, 72, 4931-4937., 2016
Rej, R. K.; Kumar, R.; Nanda, S., "Asymmetric synthesis of cytospolides C and D through successful exploration of stereoselective Julia–Kocienski olefination and Suzuki reaction followed by macrolactonization" Tetrahedron, 2015, 71, 3185-3194, 2015
Kumar, R.; Rej, R. K.; Nanda, S., "Asymmetric total synthesis of (-)-mangiferaelactone by using an appropriately substituted thiophene as a masked synthon for C-alkyl glycoside" Tetrahedron: Asymmetry, 2015, 26, 751-759, 2015
Halder J.; Das, D., "Enantioselective biocatalytic reduction of 2,2-disubstituted ethylacetoacetates: an indirect desymmetrization approach for the synthesis of enantiopure 4-hydroxy-3,3-disubstitutedpentane-2-ones. " Tetrahedron : Asymmetry, 2015, 26, 1197-1208, 2015
Rej, R.; Nanda, S. , "Chemoenzymatic asymmetric total synthesis of nonanolide (Z)-cytospolides D,E and their stereoisomers. " Eur. J. Inorg. Chem., 2014, 860-871, 2014
Rej, R.; Jana, A.; Nanda, S., "Asymmetric synthesis of naturally occurring nonenolide xyolide through cross metathesis and macrolactonization reaction. " Tetrahedron, 2014, 70, 2634-2642, 2014
Rej, R.; Pal. P. Nanda, S. , "Asymmetric synthesis of naturally occurring (-)-seimatopolides A and B. " Tetrahedron, 2014, 70, 4457-4470., 2014
Das, D.; Halder J.; Bhuniya, R.; Nanda, S. , "Stereoselecive synthesis of enantiopure oxetanes, carbohydrate mimic, epsilon-lactone, and cyclitols from biocatalytically derived beta-hydroxyesters as chiral precursors. " Eur. J. Org. Chem, 2014, 5229-5246., 2014
Pal, P. Jana, N.Nanda, S. , "Asymmetric total synthesis of paecilomyci E, 10’-epi-paecilomycin E and 6’-epi-cochliomycin C. " Org. Biomol. Chem, 2014, 12, 8257-8274, 2014
Bhuniya, R.; Nanda, S., "Asymmetric total synthesis of (-)-rasfonin" Tetrahedron, 2013, 69, 1153-1165, 2013
Jana, N.; Das, D.; Nanda, S. , "Asymmetric total synthesis of 5`-epi-cochliomycin C. " Tetrahedron, 2013, 69, 2900-2908., 2013
Rej, R. K.; Das, T.; Hajra, S.; Nanda, S., "Chemoenzymatic asymmetric synthesis of fluoxetine, atomoxetine, nisoxetine, and duloxetine. " Tetrahedron : Asymmetry, 2013, 24, 913-918, 2013

Projects

Synthetic studies towards Volvalerenol A, a unique tricyclic triterpenoid through exploitation of pseudo C2-symmetry
Client: DST-SERB
PI: Samik Nanda  |  Co-Consultant(s):
Synthetic studies towards resorcylic acid lactones (RALs) and its structural congeners through a late stage biomimetic lactonization approach
Client: CSIR
PI: Samik Nanda  |  Co-Consultant(s):
Total synthesis of anti plasmodial agent Cupacinoxepin; exploitation of C2 symmetry in synthetic planning.
Client: IIT-KGP (SGIRG) (2014-2017)
PI: Samik Nanda  |  Co-Consultant(s):
Asymmetric synthesis of small ring carbocycles and heterocycles by ketoreductase (Klebsiella pneumoniae; NBRC 3319) mediated bioreduction.
Client: BRNS (2014-2017)
PI: Samik Nanda  |  Co-Consultant(s):

Awards and Recognition

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Courses Taught

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Patents

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Research Group

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