Authors: Swagata Paul, Kanak Kanti Das, Samir Manna and Dr. Santanu PandaVol: 26 Pages: 1922-1927Journal: Chem. Eur. J Year: 2020 Posted: 23 Apr 2020
The synthesis of a diverse range of heterobiaryls has been achieved by a transition?metal?free sp2–sp2 cross?coupling strategy using lithiated heterocycle, aryl or heteroaryl boronic ester and an electrophilic halogen source. The construction of heterobiaryls was carried out through electrophilic activation of the aryl–heteroaryl boronate complex, which triggered 1,2?migration from boron to the carbon atom. Subsequent oxidation of the intermediate boronic ester afforded heterobiaryls in good yield. A comprehensive 11B?NMR study has been conducted to support the mechanism. The cross coupling between two nucleophilic cross coupling partners without transition metals reveals a reliable manifold to procure heterobiaryls in good yields. Various heterocycles like furan, thiophene, benzofuran, benzothiophene, and indole are well tolerated. Finally, we have successfully demonstrated the gram scale synthesis of the intermediates for an anticancer drug and OLED material using our methodology.<\/p>")">
“Tandem Allylation/1,2-Boronate Rearrangement for the Asymmetric Synthesis of Indolines with Adjacent Quaternary Stereocenters
Authors: S. Panda, Joseph ReadyVol: 140 Pages: 13242Journal: J. Am. Chem. Soc. Year: 2018 Posted: 22 Dec 2018
“Palladium Catalyzed Asymmetric Three Component Coupling of Boronic Esters, Indoles and Allylic Acetates
Authors: S. Panda, Joseph ReadyVol: 139 Pages: 6038Journal: J. Am. Chem. Soc. Year: 2017 Posted: 22 Dec 2018
Synthesis and Utility of Dihydropyridine Boronic Esters
Authors: S. Panda, A. Coffin, Q. N. Nguyen, Prof. D. Tantillo, Prof. J. M. Ready.Vol: 55 Pages: 2205Journal: Angew. Chem. Int. Ed. Year: 2016 Posted: 22 Dec 2018
“Synthesis of a Potential Intermediate for TMC-95A via an Organocatalyzed Aldol Reaction”
Authors: A. J. Pearson, S. Panda, S. D. Bunge.Vol: 78 Pages: 9921Journal: J. Org. Chem. Year: 2013 Posted: 22 Dec 2018
N-Prolinylanthranilic Acid Derivatives as Bifunctional Organocatalysts for Asymmetric Aldol Reactions”
Authors: S. Panda, A. J. PearsonVol: 67 Pages: 3969Journal: Tetrahedron Year: 2011 Posted: 22 Dec 2018
N-Prolinylanthranilamide Pseudopeptides as Bifunctional Organocatalysts for Asymmetric Aldol Reactions
Authors: S. Panda, A. J. Pearson.Vol: 13 Pages: 5548Journal: Org. Lett. Year: 2011 Posted: 22 Dec 2018
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