Aryne Alder-Ene Reaction Enables Arylation of Conformationally Locked Styrenes
Authors: Ballav, T.; Barman, S.; Ganesh, V.*Journal: Org. Lett. 27, 4107 Year: 2025 Posted: 17 Jul 2025
Synthesis of Dibenzopentalenes via Pd(0)-Catalyzed Cascade Coupling of gem-Dibromo Olefins
Authors: Mondal, S.; Biswas, K.; Ganesh, V.*Journal: Org. Lett. 27, 3607 Year: 2025 Posted: 15 Apr 2025
Advances in Accessing Rare Oxidation States of Nickel for Catalytic Innovation
Authors: Khamrai, A; Ghosh, S.; Ganesh, V.*Journal: Chem. Commun. 61, 3037 - 3060 Year: 2025 Posted: 15 Mar 2025
Copper(I)-Catalyzed Proto/Carboboration of Enyne Boronates for the Synthesis of Densely Substituted Diene Diboronates
Authors: Ghosh, S.; Chakrabortty, R.;† Kumar, S.;† Ganesh, V.*Journal: Adv. Synth. Catal. 367, e202401188 Year: 2025 Posted: 15 Mar 2025
Nickel-Catalyzed [2+2+2] Cyclotrimerization of Alkynes and Other Unsaturated Systems: A Literature Overview
Authors: Chakrabortty, R.;† Ghosh, S.;† Ganesh, V.*Journal: Eur. J. Org. Chem. e202400801 Year: 2024 Posted: 15 Mar 2025
Regioselective C(sp3)-Carboboration of 1,3-Diynes: A Direct Route to Fully Substituted Enyne Boronates
Authors: Ghosh, S.; Kumar, S.; Chakrabortty, R.; Ganesh, V.*Vol: 25 Pages: 6574-6579Journal: Org. Lett. 26, 6574-6579 Year: 2024 Posted: 18 Jan 2025
Diastereoselective Synthesis of Cyclopenta[c] chromanones via Pd(0)-Catalyzed [3+2] Cycloaddition
Authors: Biswas, K.; Malik, S.; Ganesh, V.*Journal: J. Org. Chem. 2024, 89, 11014-11018 Year: 2024 Posted: 16 Jan 2025
In Situ Triflation-Tandem Cross-Coupling Enables Synthesis and Photophysical Studies of Indenones and Benzofulvenes
Authors: Mondal, S.; Biswas, K.; Ganesh, V.*Vol: 366 Pages: 3277-3282Journal: Adv. Synth. Catal. 366, 3277-3282 Year: 2024 Posted: 16 Jan 2025
Regioselective C(sp3)-Carboboration of 1,3-Diynes: A Direct Route to Fully Substituted Enyne Boronates
Authors: Ghosh, S.; Kumar, S.; Chakrabortty, R.; Ganesh, V.*Journal: Org. Lett. 26, 6574-6579 Year: 2024 Posted: 17 Oct 2024
Diastereoselective Synthesis of Cyclopenta[c] chromanones via Pd(0)-Catalyzed [3+2] Cycloaddition
Authors: Krishna Biswas, Subrata Malik, Venkataraman Ganesh*Journal: J. Org. Chem. 89, 11014-11018 Year: 2024 Posted: 19 Aug 2024
Authors: Ghosh, S.; Rooj, A.; Chakrabortty, R.; Ganesh, V.*Journal: Org. Lett. 2024, 26, 4024 Year: 2024 Posted: 01 Jun 2024
We demonstrate for the first time a nickel-catalyzed diastereoconvergent reductive coupling of a heteroatom-attached allyl moiety with aldehydes, viz., O<\/em>-allyl, O<\/em>-cinnamyl salicylaldehydes, and others, to afford syn<\/em>-chromanols exclusively. The reaction proceeds through a [2 + 2 + 1] oxidative cycloaddition involving the active catalyst. This method is applicable to both terminal and internal olefin substrates. The formal syntheses of CP-199.330, CP-199.331, and CP-85.958 have been demonstrated. Control experiments, mass spectrometric analysis, and DFT studies supported the plausible mechanism and the origin of exclusive syn<\/em>-selectivity.<\/p>")">
Authors: Das, A.; Myers, D.; Ganesh, V.*; Greaney, M.*Journal: Org. Lett. 2024, 26, 2612 Year: 2024 Posted: 01 Jun 2024
We describe a transition metal-free approach to hindered 3-amino-2-aryl phenols through a cascade nucleophilic addition \/ Smiles–Truce rearrangement of a functionalized Kobayashi aryne precursor. Under anionic conditions, secondary alkyl amines add to the aryne intermediate to set up an aryl transfer from a neighboring sulfonate group. The use of a sulfonate, rather than the more typical sulfonamide, enables access to phenolic biaryl products that are important motifs in natural products and pharmaceuticals.<\/p>")">
Ni(0)-Catalyzed Regioselective [2+2+2]-Cyclotrimerization of 1,3-Diynes: An Expeditious Synthesis of Hexa-Substituted Alkynyl Benzenes
Authors: Chakrabortty, R.; Ghosh, S.; Ganesh, V.*Journal: Org. Lett. 26, 792–797 Year: 2024 Posted: 04 Apr 2024
Computational Studies on the Tropylium-Catalyzed Carboxylic Acid O-H Insertion with Diazoesters: The Role of Homoaromaticity
Authors: Anoop, A.;* Ganesh, V.*Journal: Eur. J. Org. Chem. 2024; 27, 111411 Year: 2024 Posted: 19 Jan 2024
Benchtop Nickel-Catalyzed Reductive Coupling of Aldehydes with Alkynes and Ynamides
Authors: Khamrai, A.; Ganesh, V.*Journal: Chem. Commun. 2023, 59, 11141 Year: 2023 Posted: 19 Jan 2024
Authors: Sourav Mondal, Tamal Ballav, Tofayel Sheikh Mohammad, and Venkataraman Ganesh*Vol: 25 Pages: 3941Journal: Org. Lett. 25, 3941–3945 Year: 2023 Posted: 04 Sep 2023
We report the synthesis of bis-benzofulvenes and the studies on their optical and redox properties. Bis-benzofulvenes were achieved through the Pd-catalyzed intramolecular Heck coupling followed by Ni0-mediated C(sp2)–Br dimerization. Low optical and electrochemical energy gaps of 2.05 and 1.68 eV were achieved by tuning the substituent on the exomethylene unit and the aromatic ring. The observed trends in the energy gaps were compared, and the frontier molecular orbitals were visualized using the density functional theory.<\/p>")">
Authors: Biswas, K.; Khamrai. A; Malik, S.; Ganesh, V.*Vol: 25 Pages: 1805Journal: Organic Letters 25, 1805 Year: 2023 Posted: 28 Mar 2023
We report an operationally simple route to δ-valerolactones through an organophosphorus-catalyzed borylative ring-opening\/allylation of vinylcyclopropanes providing δ-hydroxy esters stereoselectively. The δ-hydroxy esters were lactonized to obtain densely substituted δ-valerolactones. The present methodology exhibited enhanced functional group tolerance compared to the existing metal-mediated methods. A plausible mechanism for borylative ring-opening reaction has been suggested. 31P NMR studies indicated the involvement of a phosphonium zwitterionic species. The synthetic utility of the intermediate allyl boronates was demonstrated.<\/p>")">
Copper-Catalyzed Protoboration of 1,3-Diynes as a Platform for Iterative Functionalization
Authors: Ghosh, S.; Chakrabortty, R.; Kumar, S.; Das, A.; Ganesh, V.*Journal: ACS Catal. 12, 11660-11666 Year: 2022 Posted: 01 Dec 2022
Palladium-Catalyzed Dual Catalytic Synthesis of Heterocycles
Authors: Tamal Ballav, Rajesh Chakrabortty, Aniruddha Das, Suman Ghosh, Dr. Venkataraman GaneshJournal: Eur. J. Org. Chem. 10.1002/ejoc.202200553 Year: 2022 Posted: 29 Oct 2022
Recent Advances in Organophosphorus-Catalyzed Borylation and Silylation Reactions
Authors: Krishna Biswas, Aniruddha Das, Venkataraman GaneshJournal: Adv. Synth. Catal. (10.1002/adsc.202100710) Year: 2021 Posted: 22 Sep 2021
Dual Functionalization of Alkynes Utilizing the Redox Characteristics of Transition Metal Catalysts
Authors: Sudipta Ghosh, Rajesh Chakrabortty, Venkataraman GaneshJournal: ChemCatChem (Accepted) 10.1002/cctc.202100838 Year: 2021 Posted: 10 Aug 2021
Exploiting the Versatility of Palladium Catalysis: A Modern Toolbox for Cascade Reactions
Authors: Mondal, S.+; Ballav, T.+; Biswas, K.+; Ghosh, S.+; Ganesh, V.*Journal: Eur. J. Org. Chem. 10.1002/ejoc.202100312 Year: 2021 Posted: 30 Mar 2021
How to Train Free-Radicals for Organic Synthesis? A Modern Approach
Authors: Khamrai, A.; Ganesh, V.*Vol: 133 Pages: 5Journal: J. Chem. Sci. 133, 5 Year: 2021 Posted: 30 Mar 2021
Strain Release of Donor-Acceptor Cyclopropyl Boronate Complexes
Authors: Gregson, C. H. U.; Ganesh, V.; Aggarwal, V. K.Journal: Org. Lett. 21, 3412-3416 Year: 2019 Posted: 20 Nov 2019
Authors: Venkataraman Ganesh, Adam Noble, and Varinder K. Aggarwal*Journal: Organic Letters, 20, 6144 Year: 2018 Posted: 22 Dec 2018
An enantiospecific coupling between alkylboronic esters and lithiated aryl hydrazines is described. The reaction proceeds under transition-metal-free conditions and is promoted by acylation of a hydrazinyl arylboronate complex, which triggers a N−N bond cleavage with concomitant 1,2- metalate rearrangement. Judicious choice of the acylating agent enabled the synthesis of ortho- and para-substituted anilines with essentially complete enantiospecificity from a wide range of boronic ester substrates.<\/p>")">
Alkynyl Moiety for Triggering 1,2-Metallate Shifts: Enantiospecific sp2-sp3 Coupling of Boronic Esters with p-Arylacetylenes
Authors: Ganesh, V.; Odachowski, M.; Aggarwal, V. K.Journal: Angew. Chem. Int. Ed. 56, 9752 Year: 2017 Posted: 20 Nov 2019
Enantiospecific sp2-sp3 Coupling of Chiral Boronic Esters with o- and p-Phenols
Authors: Wilson, C. M.+; Ganesh, V.+; Noble, A.; Aggarwal, V. K.Vol: 56 Pages: 16318Journal: Angew. Chem. Int. Ed. 56, 16318-16322 Year: 2017 Posted: 20 Nov 2019
Synthetic Applications of Carbohydrate-derived Donor-Acceptor Cyclopropanes
Authors: Ganesh, V.; Ramusridhar, P.; Chandrasekaran, S.Journal: Isr. J. Chem. 56, 417 Year: 2016 Posted: 20 Nov 2019
Recent Advances in the Synthesis and Reactivity of Vinylcyclopropanes
Authors: Ganesh, V.; Chandrasekaran, S.Journal: Synthesis 48, 4347 Year: 2016 Posted: 20 Nov 2019
sigma–Ferrier Rearrangement of Carbohydrate Derived Vinylcyclopropanes: A Facile Approach to Oxepane Analogs
Authors: Ganesh, V.; Kundu, T.; Chandrasekaran, S.Journal: Tetrahedron, 70, 7268 Year: 2014 Posted: 20 Nov 2019
Direct Catalytic Addition of Alkyl nitriles to Aldehydes by Transition-Metal/NHC Complexes
Authors: Sureshkumar, D.; Ganesh, V.; Kumagai, N.; Shibasaki, M.Journal: Chem. Eur. J. 20, 15723 Year: 2014 Posted: 20 Nov 2019
Electrophile Induced Indirect Activation of C–C Bond of Vinylcyclopropanes: A Masked Donor–Acceptor Strategy for the Synthesis of Z–Alkylidene Furans
Authors: Ganesh, V.; Kundu, T.; Chandrasekaran, S.Journal: J. Org. Chem. 78, 380 Year: 2013 Posted: 20 Nov 2019
Bromenium Catalyzed Tandem Ring Opening/Cyclization of Vinylcyclopropanes and Vinylcyclobutanes: Metal–free [3+2+1]/ [4+2+1] Cascade for the Synthesis of Chiral Amidines and Computational Investigation
Authors: Ganesh, V.; Sureshkumar, D.; Chanda, D.; Chandrasekaran, S.Journal: Chem. Eur. J. 18, 12498 Year: 2012 Posted: 20 Nov 2019
10 Years of Click Chemistry: Synthesis and Applications of Ferrocene-Derived Triazoles
Authors: Ganesh, V.; Sai Sudhir V.; Kundu, T.; Chandrasekaran, S.Journal: Chem. Asian J. 6, 2670 Year: 2011 Posted: 20 Nov 2019
Tandem Ring Opening/Cyclization of Vinylcyclopropanes: A Facile Synthesis of Chiral Bicyclic Amidines
Authors: Ganesh, V.;+ Sureshkumar, D.;+ Chandrasekaran, S.Journal: Angew. Chem. Int. Ed. 50, 5878 Year: 2011 Posted: 20 Nov 2019
Tetrathiomolybdate Mediated Rearrangement of Aziridinemethanol Tosylates: A Thia-Aza-Payne Rearrangement
Authors: Sureshkumar, D.; Koutha S.; Ganesh, V.; Chandrasekaran, S.Journal: J. Org. Chem. 75, 5533 Year: 2010 Posted: 20 Nov 2019
Direct Synthesis of Functionalized Unsymmetrical ?-Sulfonamido Disulfides by Tetrathiomolybdate Mediated Aziridine Ring-Opening Reactions
Authors: Sureshkumar, D.; Ganesh, V.; Vidyarini, R. S.; Chandrasekaran, S.Journal: J. Org. Chem. 74, 7958 Year: 2009 Posted: 20 Nov 2019
One-Pot Synthesis of ?-Amino/?-Hydroxy Selenides and Sulfides from Aziridines and Epoxides
Authors: Ganesh, V.; Chandrasekaran, S.Journal: Synthesis 3267 Year: 2009 Posted: 20 Nov 2019
Regio- and Stereospecific Synthesis of ?-Sulfonamidodisulfides and ?-Sulfonamidosulfides from Aziridines using Tetrathiomolybdate as a Sulfur Transfer Reagent
Authors: Sureshkumar, D.; Gunasundari T.; Ganesh, V.; Chandrasekaran, S.Journal: J. Org. Chem. 72, 2106 Year: 2007 Posted: 20 Nov 2019
Conformationally Locked Bridged Bicyclic Diselenides: Synthesis, Structure, Se…O Interaction, and Theoretical Studies
Authors: Sureshkumar, D.; Ganesh, V.; Chandrasekaran, S.Journal: J. Org. Chem. 72, 5313 Year: 2007 Posted: 20 Nov 2019
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